Lipopeptide

The molecule, a lipopeptide, had a unique mechanism. ❋ MARYN MCKENNA (2010)

Enzymatic and chemical modifications of lipopeptide antibiotic A21978C: the synthesis and evaluation of daptomycin LY146032. ❋ MARYN MCKENNA (2010)

It has developed several types of resistance to vancomycin, a glycopeptide, which for decades was the MRSA drug of last resort, and is beginning to exhibit resistance to drugs in newly developed families that were intended to replace vancomycin: linezolid (Zyvox), an oxazolidinone, and daptomycin (marketed as Cubicin), a lipopeptide. ❋ MARYN MCKENNA (2010)

The Phase 2 candidate CB-183,315, a potent, oral, bactericidal lipopeptide in development for the treatment of ❋ Unknown (2010)

The Phase 2 candidate CB-183,315, a potent, oral, bactericidal lipopeptide in development for the treatment of Clostridium difficile-associated diarrhea ❋ Unknown (2010)

Bettahi I, Nesburn AB, Yoon S, Zhang X, Mohebbi A, et al. (2007) Protective immunity against ocular herpes infection and disease induced by highly immunogenic self-adjuvanting glycoprotein D lipopeptide vaccines. ❋ Christopher R. Cotter Et Al. (2010)

Gahery-Segard H, Pialoux G, Charmeteau B, Sermet S, Poncelet H, et al. (2000) Multiepitopic B - and T-cell responses induced in humans by a human immunodeficiency virus type 1 lipopeptide vaccine. ❋ Barney S. Graham Et Al. (2010)

A lipopeptide based on the M2 and HA proteins of influenza A viruses induces protective antibody ❋ David Pejoski (2010)

The company is developing new lipopeptide antibiotics similar to Cubicin and also has an active anti-viral drug discovery program. ❋ Unknown (2009)