Until now, there have been no effective drugs for treating latent EBV infection in any of the EBV-associated diseases, which in addition to mono include a subset of stomach cancers, certain types of nose-throat cancer and lymph node cancers such as lymphoproliferative disease, says lead author Shannon C. Kenney, MD. ❋ Unknown (2010)
Knowing the specific alteration that is present in an individual with X-linked lymphoproliferative syndrome (XLP) allows for other family members to undergo testing to determine whether or not they also carry this alteration in the SH2D1A gene. ❋ Unknown (2009)
This information could strengthen the conclusion that the SH2D1A alteration was linked to the diagnosis of X-linked lymphoproliferative syndrome (XLP) or XLP carrier state in the individual being tested. ❋ Unknown (2009)
In order to confirm that an individual has X-linked lymphoproliferative syndrome (XLP), most commonly a genetic test must be completed: ❋ Unknown (2009)
Provided that the male partner of a female carrier does not himself have X-linked lymphoproliferative syndrome (XLP), a female child inheriting the alteration will also be a carrier like her mother and not show symptoms of X-linked lymphoproliferative syndrome (XLP). ❋ Unknown (2009)
There are several ways that X-linked lymphoproliferative syndrome (XLP) can be diagnosed. ❋ Unknown (2009)
A blood sample is obtained from a male who has clinical symptoms of X-linked lymphoproliferative syndrome (XLP) or from a female who wants to see if she is a carrier of an SH2D1A alteration. ❋ Unknown (2009)
If a man with X-linked lymphoproliferative syndrome (and hence an SH2D1A alteration) has children with a female partner who does not carry an alteration in SH2D1A, he will either pass on a Y-chromosome to his sons (who will therefore be unaffected by the syndrome) or he will pass the X-chromosome with the SH2D1A alteration to his daughters (who will be X-linked lymphoproliferative syndrome carriers). ❋ Unknown (2009)
The diagnosis might also be considered if there is a family history where relatives were affected by illnesses found in X-linked lymphoproliferative syndrome (XLP), such as fatal Epstein-Barr virus (EBV) infection, lymphoma or hypogammaglobulinemia. ❋ Unknown (2009)
In this case, the male child would not have X-linked lymphoproliferative syndrome (XLP). ❋ Unknown (2009)
Thus, if the child born to a female X-linked lymphoproliferative syndrome (XLP) carrier is a male, there is a 50 percentchance that he will inherit the X chromosome carrying the SH2D1A alteration. ❋ Unknown (2009)
If a child has severe symptoms in response to infection with Epstein-Barr virus (EBV), a physician may consider a diagnosis of X-linked lymphoproliferative syndrome (XLP). ❋ Unknown (2009)
This child would not be a carrier of X-linked lymphoproliferative syndrome (XLP) and therefore, she could not pass the SH2D1A alteration to her future children. ❋ Unknown (2009)
However, even if an alteration in this gene is not found, a child can still have a diagnosis of X-linked lymphoproliferative syndrome (XLP) based on the clinical symptoms and other laboratory test results. ❋ Unknown (2009)
How do you diagnose X-linked lymphoproliferative (XLP) syndrome? ❋ Unknown (2009)
If this were the case, the child would have X-linked lymphoproliferative syndrome (XLP). ❋ Unknown (2009)
How do you test for X-linked lymphoproliferative (XLP) syndrome? ❋ Unknown (2009)
If an alteration is identified, one can next examine whether the alteration has been previously reported in other individuals with X-linked lymphoproliferative syndrome (XLP). ❋ Unknown (2009)
