Metabolite

First they took cerebral spinal fluid from 132 juvenile rhesus monkeys and analyzed it for a serotonin metabolite, called 5-HIAA, that’s considered a reliable indicator of how much serotonin the nervous system is processing. ❋ Unknown (2009)

For example, phenoxybenzamine (Dibenzyline®), a drug given to relieve hypertension, is biotransformed into a metabolite, which is the active agent. ❋ Unknown (2008)

This agent was not described as metabolite in report, but it should be noted that diazepam breaks down into oxazepam. ❋ Unknown (2007)

The case focuses on a patent that covers the concept of adjusting the dosage of a drug, thiopurine, based on the concentration of a particular chemical called a metabolite in the patient's blood. ❋ Timothy B. Lee (2011)

The machine was not calibrated to recognize there can be an interfering substance, known as metabolite, which exists naturally in the metabolism of some patients and in rare instances can interfere with cyclosporine causing the machine to show artificially low levels of the drug. ❋ Barb Sweet (2010)

This is in contrast to the pharmacokinetics of Clopidogrel's active metabolite, which is affected by genetic variations in CYP2C19. ❋ Unknown (2009)

But Prometheus hasn't patented the idea of tailoring drug doses to metabolite levels, but rather one specific, sophisticated method for doing so. ❋ Unknown (2011)

Wang and his coauthor, Dr. Robert Gerszten, are co-inventors on patent applications related to metabolite predictors of diabetes. ❋ Unknown (2011)

In 1948, John Cade, a psychiatrist in a mental institution in Australia, hypothesized, incorrectly, that the manic depressive state might be due to either an excess or lack of some metabolite. ❋ Unknown (2010)

The independent Tribunal had found that Richard Gasquet, a 23-year-old French tennis player, committed a Doping Offence in that a sample provided by Mr Gasquet on 28 March 2009 at the ATP event in Miami, USA, contained benzoylecgonine, a metabolite of cocaine, and a banned substance. ❋ Unknown (2011)

A metabolite contributing to morbidity and mortality. ❋ Unknown (2010)

In the late 1990s, two Canadian researchers at Hopital Sainte-Justine conducted clinical trials to measure how patients process the drug, a complex process that was not fully understood, and to develop a treatment protocol for optimal doses calibrated to individual metabolite levels. ❋ Unknown (2011)

At times of stress, he argues, we are physiologically in "survival mode", prompting the release of testosterone and its bioactive metabolite, DHT. ❋ Unknown (2011)

Mayo claims that Prometheus's test is essentially unpatentable—that the dosage correlations with metabolite levels are an abstract idea and natural phenomenon. ❋ Unknown (2011)

In this way, they move from metabolite analysis or biochemical markers to disease diagnosis involving an enzyme, transport or structural protein, etc. to the gene defect and mutation analysis if feasible. ❋ Unknown (2010)

Instead, they performed typical laboratory research: measuring the levels of a drug metabolite and correlating them with whether the drug was effective or had toxic side effects. ❋ Unknown (2011)

Their research produced the "laboratory insights" that there is a greater likelihood of toxicity above a particular metabolite level and a lower likelihood of efficacy below a particular metabolite level. ❋ Unknown (2011)

Nieto, who spent 2010 with low Class A Hagerstown, tested positive for Oxandrolone, a synthetic anabolic steroid, and metabolite. ❋ Dave Sheinin (2011)