Mineralocorticoid

Aldosterone is also unusual, for a mineralocorticoid, in possessing an oxygen at carbon-n. ❋ Asimov, Isaac (1963)

In 1953, more than a decade after the discovery of four important glycocorticoids and two important mineralocorticoids, there came the rather surprising isolation of another mineralocorticoid. ❋ Asimov, Isaac (1963)

In consequence the new mineralocorticoid was named aldosterone (al-dos'ter-ohn) - ❋ Asimov, Isaac (1963)

Why this should be we cannot yet tell, but this point of putting the oxygen on, then neutralizing it, results in a mineralocorticoid that is much more powerful than any of those in which the oxygen is absent in the first place. ❋ Asimov, Isaac (1963)

In in vitro binding affinity and functional assays this compound has no affinity for the progesterone (PR), estrogen (ER), androgen (AR) or mineralocorticoid (GR-I) receptors.

In in vitro binding affinity and functional assays neither of these compounds have affinity for the progesterone (PR), estrogen (ER), androgen (AR) or mineralocorticoid (GR-I) receptors. ❋ Unknown (2010)

De Bono said patients taking abiraterone generally avoided the unpleasant side-effects associated with chemotherapy, although they did have more mineralocorticoid-related side effects. ❋ Unknown (2010)

A 35 year old woman was taking life long glucocorticoid (dexamethasone) and mineralocorticoid (fludrocortisone, Florinef, Squibb) replacement for congenital adrenal hyperplasia caused by 21-hydroxylase deficiency. ❋ Unknown (2009)

Patients with congenital adrenal hyperplasia arising from mutations of 11β-hydroxylase, the final enzyme in the glucocorticoid biosynthetic pathway, exhibit glucocorticoid deficiency, adrenal hyperplasia driven by unsuppressed hypothalamo-pituitary-adrenal activity, and excess mineralocorticoid activity caused by the accumulation of deoxycorticosterone. ❋ Unknown (2009)

The null mice exhibited glucocorticoid deficiency, mineralocorticoid excess, adrenal hyperplasia, mild hypertension, and hypokalemia. ❋ Unknown (2009)

Sebastian A, Sutton JM, Hulter HN, Schambelan M, Poler SM: Effect of mineralocorticoid replacement therapy on renal acid base homeostasis in adrenalectomized patients. ❋ Unknown (2008)

: K+ deprivation potentiates the renal alkalosis producing effect of mineralocorticoid. ❋ Unknown (2008)

Sebastian A: Impaired renal H+ secretion and NH3 production in mineralocorticoid deficient glucocorticoid - replete dogs. ❋ Unknown (2008)

: K+ deprivation potentiates the renal acid excretory effect of mineralocorticoid: ❋ Unknown (2008)

: Effects of dietary potassium depletion and mineralocorticoid excess on renal Cl conservation in the dog. ❋ Unknown (2008)