Loss of KLP-19 polar ejection force causes misorientation and missegregation of holocentric chromosomes. ❋ Unknown (2006)
A growing body of evidence suggests that tumorigenesis, the formation of new tumors, can be attributed to some extent to errors occurring at the mitotic checkpoint, a major cell cycle control mechanism that acts to prevent chromosome missegregation. ❋ Unknown (2010)
Ubiquitin-conjugating enzyme promotes chromosome missegregation and tumor formation ❋ Unknown (2010)
The researchers induced missegregation and then looked for cells that had gained or lost a fluorescent mark within their genome. ❋ Unknown (2010)
Cells lacking p53 became aneuploid after induced missegregation, indicating that the p53 pathway normally serves to limit the propagation of cells with odd numbers of chromosomes. ❋ Unknown (2010)
In 2008, Sarah Thompson and Duane Compton, from Dartmouth Medical School, revealed that most CIN in tumor cells was caused by incorrect attachments between mitotic spindle microtubules and kinetochores, and that inducing misattachments in normal cells was sufficient to generate high rates of chromosome missegregation. ❋ Unknown (2010)
A recent study demonstrated that chromosome missegregation initiates tumorigenesis by causing cells to lose tumor suppressors like p53. ❋ Unknown (2010)
How is p53 activated by chromosome missegregation? ❋ Unknown (2010)
Dr Austen Ganley - A spanner in the works: role of the ribosomal DNA repeats in chromosome missegregation ($860,000). ❋ Unknown (2010)
"By combining loss of p53 with increased missegregation rates, we can convert a diploid cell into something?. that looks like a tumor cell," says Compton. ❋ Unknown (2010)
Compromise in Aurora B activity or condensin-deficiency results in the same (epistatic) missegregation. ❋ Alexander Samoshkin Et Al. (2009)
Condensin-depleted metazoan cells enter anaphase accompanied by chromosome missegregation ❋ Alexander Samoshkin Et Al. (2009)
In tests on mice, the researchers found that a cell was less able to suppress tumors if there was incomplete mitosis - the term for the division of a chromosome - that resulting in misalignment or missegregation, when a cell is missing a chromosome. ❋ Unknown (2009)
The decreased levels of crossovers are generally thought to cause increased levels of homolog missegregation, resulting in decreased viability of gametes, known as spores in budding yeast. ❋ Unknown (2009)
In tests on mice, the researchers found that a cell was less able to suppress tumours if there was incomplete mitosis -- the term for the division of a chromosome -- that resulting in misalignment or missegregation, when a cell is missing a chromosome. ❋ Unknown (2009)
Moreover, recovery from mitosis-inhibition by monastrol revealed a high incidence of merotelic attachment that was nearly identical with condensin depletion, Aurora B inactivation, or both, indicating that the Aurora B dysfunction is the key defect leading to chromosome missegregation in condensin-depleted cells. ❋ Alexander Samoshkin Et Al. (2009)
Absence of condensins and/or CENP-A insufficiency produced a specific kinetochore defect, such that a functional mitotic checkpoint cannot prevent chromosome missegregation resulting from improper attachment of sister kinetochores to spindle microtubules. ❋ Alexander Samoshkin Et Al. (2009)
To the contrary, we have found that unresolved merotelic attachment, as opposed to continuing pairing of sister chromatids after anaphase onset, is the primary contributor to missegregation that is accompanied by DNA damage late in mitosis. ❋ Alexander Samoshkin Et Al. (2009)
