RAD51C in a Fanconi anemia-like disorder, while a second study reports monoallelic mutations in the same gene associated with increased breast cancer … ❋ Fiona Vaz (2010)
In index cases from 1,100 German families with gynecological malignancies, we identified six monoallelic pathogenic mutations in ❋ Alfons Meindl (2010)
PTPN2 in individuals 1 to 7, and monoallelic deletion of ❋ Maria Kleppe (2010)
To understand some of the mechanisms involved, we examined the role of monoallelic loss or Atm and Brca1 on cell transformation and apoptosis induced by radiation. ❋ Fengtao Su (2010)
For each parameter set a random initial condition was chosen, and the biallelic and monoallelic equations were integrated numerically until a stable state was reached. ❋ Arne B. Gjuvsland Et Al. (2010)
The classical concepts of dominant or additive gene actions do not follow from whether the monoallelic contributions of the two different alleles in the heterozygote act in an additive way or not, but are given by a specific relationship between the degree of allele interaction for all the three genotypes. ❋ Arne B. Gjuvsland Et Al. (2010)
In order to avoid null alleles, datasets in which one of the homozygotes gave a steady state level was set equal to zero if the sum of the monoallelic phenotypes differed less than 5% from the biallelic phenotype. ❋ Arne B. Gjuvsland Et Al. (2010)
Three of the affected females had a monoallelic homozygous mutation, four had heterologous or mosaicism biallelic mutations, and the remainder had three different mosaic mutations. ❋ Tomoji Mashimo Et Al. (2010)
Furthermore, the occurrence of monoallelic maternal expression of STAT5A was significantly higher in blastocysts, while paternal expression was more frequent in degenerative embryos. ❋ Unknown (2009)
Results: We found three patients with moderate to severe CH who had biallelic mutations in TSHR and three patients with mild CH who had monoallelic mutations. ❋ Unknown (2009)
In cell samples of each deletion-carrying individual, an aberrant, reversed pattern of replication is delineated, namely, where a monoallelic gene replicates more synchronously than a biallelic gene. ❋ Unknown (2009)
Several dozen quantitative trait loci, containing one gene or several genes, may be involved in anxiety regulation, and most of them are yet to be identified Further studies will focus on the importance of the (grand) parental background for anxiety-related behavior, as genes regulated by (grand) parent-specific epigenetic modifications can lead to monoallelic gene expression ❋ Unknown (2009)
IGF2 (insulin-like growth factor 2) is expressed uniquely from the parental allele achieved by monoallelic methylation of the imprinting control region (ICR) at 11p15. 5 ❋ Ian M. Smith Et Al. (2009)
The research also adds important insights into the controversy surrounding whether or not having just one mutation (or monoallelic mutation) does raise an individual's risk of bowel cancer. ❋ Unknown (2009)
