Mutationally

It can be shown by a nonlinear game model, incorporating mutation of a hypercycle, that the selection properties of hypercycles make them inefficient information integrators as they cannot compete favourably with all kinds of less efficient information carriers or mutationally coupled hypercycles. ❋ Unknown (2009)

To estimate the divergence time within haplogroup P, we first counted the number of substitutions [the parameter 'rho' (ρ)] between each of the CPC98 and DQ124389 samples and an inferred mutationally-equidistant ancestral sequence and multiplied by the previously used rate estimate of ~3,172 years per substitution in the coding region of the mtDNA genome ❋ Ceiridwen J. Edwards Et Al. (2010)

Reports to date about the role of IDH1 have suggested that the gene functions as a tumor suppressor that, when mutationally inactivated, may contribute to brain tumor growth.

RET is mutationally activated in papillary thyroid cancer (PTC) and in both familial and sporadic forms of medullary thyroid cancer (MTC).

MET is mutationally activated in some tumor types, such as hereditary and sporadic papillary renal cell carcinoma and some head and neck cancers.