Abstracts already released suggest that the studies are going to point to much bigger potential for '424 beyond its lead indication myelofibrosis, which is already viewed as a blockbuster opportunity. ❋ Unknown (2009)
NEW ORLEANS ― A first-in-its class oral medication provides significant and durable relief for patients with a rare, debilitating and lethal bone marrow disorder called myelofibrosis, researchers at The University of Texas M. ❋ Unknown (2009)
Incyte Corp.'s Jakafi pill obtained U.S. Food and Drug Administration approval Wednesday, making it the first drug approved specifically for myelofibrosis, a rare bone-marrow disease, according to the government agency. ❋ Melodie Warner (2011)
Novartis, based in Basel, Switzerland, said the study showed treatment with ruxolitinib, also known as INC424, provided a statistically significant reduction in spleen size in patients with different forms of myelofibrosis when compared with the best available therapy. ❋ Anita Greil (2011)
The bone marrow of people with myelofibrosis is replaced by scar tissue, which can cause an enlarged spleen, anemia, decreased white blood cells and platelets. ❋ Melodie Warner (2011)
An enlarged spleen is one of the characteristics of myelofibrosis. ❋ Anita Greil (2011)
ZURICH— Novartis AG said Tuesday an experimental drug for the treatment of myelofibrosis, a rare form of blood cancer, met the goals of a late-stage study, which should pave the way to begin filing the drug for regulatory approvals in the second quarter. ❋ Anita Greil (2011)
*** Pharmaceuticals Novartis said an experimental drug for the treatment of myelofibrosis, a rare form of blood cancer, met the goals of a late-stage study, which should pave the way to file the drug for regulatory approval in the second quarter. ❋ Unknown (2011)
The cause of myelofibrosis is unknown, and there are few treatment options. ❋ Anita Greil (2011)
Fisher died Friday at his home in Rye, N.Y., of myelofibrosis, a rare blood disease, family friend Nicole Fiftal said Wednesday. ❋ Bill Crider (2010)
Within weeks Roald was back at the John Radcliffe Hospital in Oxford, where tests began to suggest that his anemia was evolving into myelofibrosis—a rare form of leukemia. ❋ Donald Sturrock (2010)
Dave Fisher, 69, a founding member and lead singer of the 1960s folk group the Highwaymen, whose recording of the Civil War anti-slavery song "Michael, Row the Boat Ashore" became a surprise pop hit in 1962, died May 7 at his home in Rye, N.Y., of myelofibrosis, a rare blood disease. ❋ Unknown (2010)
Abrahams believes the company is undervalued, based mostly on 424s potential in treating myelofibrosis, Polycythemia vera, and Essential thrombocytosis, and in part, on the early promise of rheumatoid arthritis drug INCB28050. ❋ Unknown (2010)
He expects positive data from the phase III COMFORT-1 trial of INCB18424, which treats myelofibrosis at the end of 2010. ❋ Unknown (2010)
Causes of a high MCV include liver disease, alcohol abuse, hypothyroidism, reticulocytosis, marrow aplasia, vitamin B12 or folic acid deficiency, and myelofibrosis. ❋ MEHMET C. OZ (2007)
