Myocytes

The technique tracks the diffusion of water throughout the myocardium (the heart's muscular wall comprising interconnected sheets of muscle cells called myocytes). ❋ MD Westby G. Fisher (2010)

When we are in good health the ratio of myocytes to fibroblasts is about 70/30. ❋ Unknown (2009)

But as we age, the balance of these cells in our hearts shift, and often the fibroblasts become more prevalent than the myocytes. ❋ Unknown (2009)

The adult heart contains cardiac stem cells (CSCs) that are self-renewing, clonogenic (able to produce identical daughter cells), and multipotent-ie, they differentiate into all three major cardiac lineages (myocytes, vascular smooth muscle cells, and endothelial cells). ❋ Larry Husten (2011)

(A) Representative Western blot from myocytes transduced with R193H cTnI, A63V Tm. or both R193H cTnI and A63V Tm. Non-transduced myocytes served as controls. ❋ Jennifer Davis Et Al. (2010)

Alternatively experience with isolating ventricular myocytes and cardiac electrophysiology would also be valuable. ❋ Unknown (2010)

Bennett CN, Favre EG, Day SM, Metzger JM (2004) Parvalbumin corrects slowed relaxation in adult cardiac myocytes expressing hypertrophic cardiomyopathy-linked alpha-tropomyosin mutations. ❋ Jennifer Davis Et Al. (2010)

Scott IR, Gwyther RJ, Peyman A, Chadwick P, et al. (2005) An investigation of the effects of TETRA RF fields on intracellular calcium in neurones and cardiac myocytes. ❋ Rodney P. O'Connor Et Al. (2010)

(HCM), R193H cTnI (RCM), and A63V+R193H transduced myocytes. ❋ Jennifer Davis Et Al. (2010)

Kim SJ, Iizuka K, Kelly RA, Geng YJ, Bishop SP, et al. (1999) An alpha-cardiac myosin heavy chain gene mutation impairs contraction and relaxation function of cardiac myocytes. ❋ Jennifer Davis Et Al. (2010)

Myocytes with A63V+R193H had a phenotype similar to R193H myocytes, as A63V+R193H myocytes also transitioned to short resting sarcomere lengths independent of elevated diastolic Ca ❋ Jennifer Davis Et Al. (2010)

WASHINGTON - For the first time, Spanish researchers have used adult cells extracted from human heart tissue to turn stem cells from adipose tissue into cardiac myocytes. ❋ Unknown (2010)

Here, dual gene transfer to isolated adult rat cardiac myocytes was used to determine the primary effects of co-expressing two different CM-linked mutant proteins on intact cardiac myocyte contractile physiology. ❋ Jennifer Davis Et Al. (2010)

Post digestion the myocytes were resuspended in DMEM (Dulbecco's Minimum Eagle Media) plus 5% fetal bovine serum (FBS) and approximately 20,000 cells were plated on laminin-coated coverslips and incubated for 2 hours. ❋ Jennifer Davis Et Al. (2010)

Due to the way the myocytes are organized, the movement of water is restricted, so tracking the location of water molecules can reveal valuable information about the structure of the heart in a non-invasive way. ❋ MD Westby G. Fisher (2010)

Metzger JM (1995) Myosin binding-induced cooperative activation of the thin filament in cardiac myocytes and skeletal muscle fibers. ❋ Jennifer Davis Et Al. (2010)

This suggests that cTnIR193H has a dominant effect over TmA63V to shortening resting sarcomere lengths in intact cardiac myocytes. ❋ Jennifer Davis Et Al. (2010)

Cell therapy approaches include attempts to reinitiate cardiomyocyte proliferation in the adult, conversion of fibroblasts to contractile myocytes, conversion of bone marrow stem cells into cardiomyocytes, and transplantation of myocytes or other cells into injured myocardium. ❋ Unknown (2010)

The cTnCG159D CM mutant alone had the opposite effect such that resting sarcomere lengths were significantly longer than both WT and R193H myocytes, in addition to having elevated resting diastolic Ca ❋ Jennifer Davis Et Al. (2010)