Researchers wrote, "Cannabinoids offer a multi-faceted approach for the treatment of Alzheimer's disease by providing neuroprotection and reducing neuroinflammation, whilst simultaneously supporting the brain's intrinsic repair mechanisms by augmenting neurotrophin expression and enhancing neurogenesis (the formation of new brain cells)." ❋ Unknown (2008)
But there's also a number of these proteins or molecules called neurotrophins, and some of them are produced in the brain, such as the brain- derived neurotrophin factor or BDNF, and some of them are produced in the periphery, such as IGF1 or insulin-like growth factor 1 produced in the muscles and other regions of the periphery. ❋ Unknown (2011)
And IGF1 can cross the blood-brain barrier, go into the brain, and it seems to be an early point in this molecular cascade or pathway which stimulates the next neurotrophin, BDNF, which stimulates in turn neurogenesis and new connections and so forth. ❋ Unknown (2011)
Previous studies have linked neurotrophin receptor-interacting MAGE protein to the bone morphogenic protein signaling pathway and its effect on p38 mediated apoptosis of neural progenitor cells via the XIAP-Tak1-Tab1 complex. ❋ Unknown (2010)
"There is a lot of data from a lot of different sources that say that something is wrong with the neurotrophin system in people that develop [a tendency toward] suicide," confirmed Keith Young, vice chair of research psychiatry and behavioral science at Texas A&M Health Science Center College of Medicine, in Temple. ❋ Unknown (2010)
Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin which plays survival - and growth-promoting activity in neuronal cells and it is involved in cellular plasticity mechanisms as it controls activity dependent synaptic transmission. ❋ Unknown (2010)
From the analysis of the data from schizophrenia sample, it can be observed that the strong separation from controls is due to protein analytes belonging to the growth factors and neurotrophin family, such as BDNF, EGF or stem cell factor, and to a lesser extent from member of the chemokine/cytokine family. ❋ Enrico Domenici Et Al. (2010)
The most relevant receptors for PNS development that we have detected in human NPs include the Sonic hedgehog receptor PTCH1, neurotrophin receptors TrkA and TrkB, and the BMP receptors BMPR1 and BMPR2, which are known to be involved, in proliferation and survival of sensory and autonomic neurons ❋ Moran Valensi-Kurtz Et Al. (2010)
His work suggests that these changes are mediated by the inhibition of the N-methyl-D-aspartate receptor (NMDAR), disrupting the release of the trans-synaptic signaling neurotrophin, brain-derived neurotrophic factor (BDNF). ❋ Unknown (2010)
Initially, neurons of the inner ear require brain-derived neurotrophic factor (Bdnf) and neurotrophin 3 (Ntf3) from the otic placode, the sensory epithelium from which the cells are derived. ❋ Unknown (2010)
