Two of the carbonaceous chondrites contained a diverse array of nucleobases and structurally similar compounds known as nucleobase analogs. ❋ Charles Q. Choi (2011)
But Powner et al. 2 revive the prospects of the 'RNA first' model by exploring a pathway for pyrimidine ribonucleotide synthesis in which the sugar and nucleobase emerge from a common precursor (Fig. 1b). ❋ Unknown (2010)
In this pathway, the complete ribonucleotide structure forms without using free sugar and nucleobase molecules as intermediates. ❋ Unknown (2010)
A complex web of reactions — with phosphate acting as a crucial catalyst at several steps along the way — produced a small molecule called 2-aminooxazole, which can be viewed as a fragment of a sugar joined to a piece of a nucleobase. lol. ❋ Unknown (2009)
For 40 years, efforts to understand the prebiotic synthesis of the ribonucleotide building blocks of RNA have been based on the assumption that they must have assembled from their three molecular components: a nucleobase (which can be adenine, guanine, cytosine or uracil), a ribose sugar and phosphate. ❋ Unknown (2010)
These creative chemists abandoned the tradition of attempting to make nucleotides by joining a nucleobase, sugar and phosphate. ❋ Unknown (2009)
"Finding nucleobase compounds not typically found in Earth's biochemistry strongly supports an extraterrestrial origin," Cleaves said. ❋ Unknown (2011)
Intriguingly, three of these nucleobase analogs are very rare in Earth biology, and were not found in soil and ice samples from the areas near where the meteorites were collected at the parts-per-billion limits of their detection techniques. ❋ Unknown (2011)
Lab experiments showed that chemical reactions of ammonia and cyanide, compounds that are common in space, could generate nucleobases and nucleobase analogs very similar to those found in the carbonaceous chondrites. ❋ Unknown (2011)
They also discovered that none of the nucleobase analogs found in the heart of these meteorites were present in the meteorite environment. ❋ Jesus Diaz (2011)
Callahan and his team ruled out any potential terrestrial contamination, demonstrating that these nucleobases were produced in a chemical, non-biological reaction: ""In the lab, an identical suite of nucleobases and nucleobase analogs were generated in non-biological chemical reactions containing hydrogen cyanide, ammonia, and water. ❋ Jesus Diaz (2011)
It fills the vacant space of the absent template nucleobase and thereby mimics a pyrimidine nucleobase directing for preferential purine incorporation opposite abasic residues because of enhanced geometric fit to the active site. ❋ Samra Obeid (2010)
Nucleosides are created when a nucleobase attaches to a ribose sugar. fatty acids. ❋ Unknown (2010)
These peptides interact with the same nucleobases found in DNA, but each nucleobase is bound to an organic compound known as a thioester. ❋ Unknown (2009)
Alnylam announced today the issuance or grant of the following new patents owned, controlled, or licensed by Alnylam in the RNAi therapeutics field: the Stoffel patent, which is non-exclusively licensed to Regulus Therapeutics, was issued by the USPTO (7,585,969) and covers isolated DNA or RNA molecules having the nucleobase sequence of miR-375, or the nucleobase sequence of a miR-375 precursor, with or without a variety of chemical modifications; and,
