Nucleolar

In addition, fixed cytogenetic differences include a centromeric shift, heterochromatic differences on autosomal pairs 1–6, and the number of nucleolar organizer regions. ❋ Unknown (2008)

Noncoding regulatory RNAs - RNAs that are not translated into protein - include the small nuclear RNAs (snRNAs), the small nucleolar RNAs (snoRNAs), the XIST RNA that mediates mammalian X-chromosome silencing, microRNAs, riboswitches, and the RNA component of the enzyme telomerase. ❋ Unknown (2007)

There is a strong nucleolar signal in restrictive conditions for Ins7/9 and Ins15 consistent with defects in early processing steps. ❋ Clément Bellemer Et Al. (2010)

PJ (2004) Cell and molecular biology of nucleolar assembly and disassembly. ❋ Clément Bellemer Et Al. (2010)

Bortolin ML, Kiss T (1997) Site-specific pseudouridine formation in preribosomal RNA is guided by small nucleolar RNAs. ❋ Clément Bellemer Et Al. (2010)

These pre-rRNA processing defects are consistent with the nucleolar accumulation observed with the D-A2 probe by FISH, and resembles the molecular phenotypes observed upon depletion of Nhp2p or Utp15p: Utp15p was proposed to be required for optimal rRNA synthesis ❋ Clément Bellemer Et Al. (2010)

Our screen revealed interactions with mutants affected at various stages during ribosome biogenesis, from early nucleolar steps to nuclear export. ❋ Clément Bellemer Et Al. (2010)

Gallagher JE, Compagnone-Post PA, Mitchell BM, Porwancher KA, et al. (2002) A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. ❋ Clément Bellemer Et Al. (2010)

Δbud23; and mutants affected in early, nucleolar steps in ribosome biogenesis, such as ❋ Clément Bellemer Et Al. (2010)

Empty triangles point towards DAPI (nucleoplasmic) staining; white triangles point towards ITS1 nucleolar staining. ❋ Clément Bellemer Et Al. (2010)

We identified 117 rhesus monkey ncRNAs, including 80 small nucleolar RNAs (snoRNAs), 29 other types of known RNAs (snRNAs, Y RNA, and others), and eight unclassified ncRNAs. ❋ Unknown (2010)

Miller L, Daniel JC (1977) Comparison of in vivo and in vitro ribosomal RNA synthesis in nucleolar mutants of ❋ Vincent Gache Et Al. (2010)

These modifications are catalyzed by small nucleolar ribonucleoparticles (snoRNPs) through specific base-paring between their RNA component (snoRNA) with the surrounding of the position to be modified. ❋ Clément Bellemer Et Al. (2010)

Previous studies have suggested that mutations in nucleolar proteins involved in ribosome assembly result in ribosomal stress and nucleolus disruption resulting in the release of these three RPs (L5, L11, and L23). ❋ Unknown (2009)

Various studies have demonstrated that mutations in nucleolar proteins involved in rRNA synthesis or ribosomal subunit assembly affect ribosome synthesis and activate a p53 response through a nucleolus mediated stress ❋ Unknown (2009)

We assume that in case of an RP (L11) deficiency, ribosomal subunit assembly will be severely affected and several nucleolar proteins that would otherwise participate in the assembly may remain unutilized. ❋ Unknown (2009)

Accumulation of defective ribosomes due to RP deficiency would be sensed as a stress signal, presumably a nucleolar stress, leading to programmed cell death. ❋ Unknown (2009)

Interestingly, we observed upregulation of bop1, rrs1, and pes, nucleolar proteins required for the nuclear assembly and export of the 60S pre-ribosomal subunit ❋ Unknown (2009)

Cylene has created a diverse portfolio of product candidates, including novel inhibitors of cancer-linked serine / threonine protein kinases, as well as innovative nucleolus targeting agents (NTAs) that target the abnormal nucleolar functions of cancer cells and selectively kill cancer cells. ❋ Unknown (2009)