High-level quality research projects supported by the INCa through the Cancéropôles networks should allow to better understand the molecular mechanisms involved in oncogenesis which is crucial to define new therapeutic targets and to develop innovative treatments for the benefit of all patients. ❋ Unknown (2009)
The other class, that of anti-oncogenes or tumor suppressors, is recessive in oncogenesis; cancer results when both normal copies have been mutated or deleted. ❋ Siddhartha Mukherjee (2010)
POK proteins are critical in embryonic development, cellular differentiation and oncogenesis, according to the National Cancer Institute. ❋ Unknown (2005)
Incorporation of this foreign DNA may lead to mutations and oncogenesis by several possible mechanisms: ❋ Unknown (2004)
Richard Shope, Evolutionary episodes in the concept of viral oncogenesis, Perspectives Biol. ❋ Unknown (1972)
As is the case with AGAP2, and all other predictions regarding driver genes, definitive evidence regarding the role of these genes in GBM oncogenesis can only be provided by further functional studies. ❋ Ethan Cerami Et Al. (2010)
Altieri will also be the West Philadelphia institute's chief scientific officer and professor in the Wistar molecular and cellular oncogenesis program. ❋ Unknown (2010)
There are 'driver' somatic mutations which are the main contributors to the development of the cancers, whereas most somatic point mutations are likely to be 'passengers' that do not contribute to oncogenesis ❋ Sungsam Gong Et Al. (2010)
More information: CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis. ❋ Unknown (2010)
The intimate connection between tetraploidy, aneuploidy and cancer development suggests that Nek7 deregulation can induce oncogenesis. ❋ H Salem (2010)
Many of these miRNAs were upregulated in cancers and might serve as modulators of oncogenesis. ❋ S Wu (2010)
A deeper understanding of molecular abnormalities at a pathway level [involving gene expression and biochemical reactions that transmit information within and between cells] may help dissect the complex mechanisms of lung cancer oncogenesis [development of tumors] ❋ Editors (2010)
Her work has continued today to understand how breakpoints influence the expression of microRNAs involved in oncogenesis. ❋ Abel Pharmboy [email protected] (2010)
AGAP2 may therefore indeed be a driver in GBM oncogenesis, and may represent an alternative or additional means by which glioblastoma tumor cells activate the PI3K pathway, and its downstream effects, including cell proliferation, inhibition of apoptosis, and tumor invasiveness. ❋ Ethan Cerami Et Al. (2010)
