Figure 4: Detection of calcium-dependent calmodulin conformational changes and HPV-derived oncoproteins. ❋ Dong Cai (2010)
/GBP family of glycogen synthase kinase 3β (Gsk3b) - binding oncoproteins are recognized as potent activators of the Wnt ❋ R Van Amerongen (2010)
He and his colleagues also want to know whether KEAP1 works on other known oncoproteins. ❋ Unknown (2009)
Omacetaxine has a novel mechanism of action, specifically binding to the ribosomal A-site cleft and inhibiting protein translation of short-lived oncoproteins that are upregulated in leukemic cells (particularly Cyclin-D1, Mcl-1 and c-Myc). ❋ Unknown (2009)
HPV E6 and E7 viral genes are usually expressed in these tumors, suggesting key roles for their gene products, the E6 and E7 oncoproteins, in inducing malignant transformation. ❋ Unknown (2009)
Jackman A, Pei XF, Schlegel R, Sherman L (1998) Induction of apoptosis in human keratinocytes containing mutated p53 alleles and its inhibition by both the E6 and E7 oncoproteins. ❋ Unknown (2009)
Western blot detection of the wild-type and mutant viral oncoproteins (anti-HA Ab) in HPV-16 E7 - and in HPV-16 E7 ❋ Unknown (2009)
This suggests key roles for their respective gene products, the E6 and E7 oncoproteins, in inducing malignant transformation ❋ Unknown (2009)
Duensing S, Lee LY, Duensing A, Basile J, Piboonniyom S, et al. (2000) The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle. ❋ Unknown (2009)
Felsani A, Mileo AM, Paggi MG (2006) Retinoblastoma family proteins as key targets of the small DNA virus oncoproteins. ❋ Unknown (2009)
The expression of these oncoproteins favors the rise of and selection for clones with a high frequency of transformation. ❋ Unknown (2009)
"Omacetaxine works by a completely different mechanism, inhibiting the synthesis of certain oncoproteins instead of directly attacking Bcr-Abl," Cortes said. ❋ Unknown (2009)
[31] or HPV-16-infected keratinocytes, where viral oncoproteins expression is associated with increased resistance to UV radiation ❋ Unknown (2009)
Omacetaxine has a novel mechanism of action, specifically binding to the ribosomal A-site cleft and inhibiting protein translation of short-lived oncoproteins that are up-regulated in leukemic cells (particularly ❋ Unknown (2010)
"Results presented at the AACR meeting in April 2009 and the Molecular Targets and Cancer Therapeutics meeting in November 2009 demonstrated that the Hsp90 inhibitor STA-9090 has greater potency compared to the first generation Hsp90 inhibitors, such as 17-AAG, to destabilize critical oncoproteins and components of their signaling pathways, including EGFR, ❋ Unknown (2009)
