Further, mice mildly overexpressing SIRT1 seemed to be protected from metabolic diseases at an older age, even when challenged with a high-fat diet. ❋ Ph.D. Jay Williams (2011)
When he treated Her-2 overexpressing breast cancer cells in a dish with the antibody, the cells stopped growing, then involuted and died. ❋ Siddhartha Mukherjee (2010)
Imagine, for example, that you carry the genes for psychosis, and a fetal injection could prevent your unborn child from ever overexpressing those genes, rather than becoming bipolar or schizophrenic. ❋ Unknown (2009)
To test their hypothesis, the researchers exposed aromatase-overexpressing MCF-7/Ac1 breast cancer cells to the full-length form of cyclin E or to the LMW-E forms ( "low forms"). ❋ Editors (2010)
When compared to the corresponding controls, both cell lines overexpressing miR-30a or -191 do not demonstrate any significant changes in cell cycle distribution, cell proliferation, adherent colony formation, soft agar colony formation, xenograft formation in a subcutaneous SCID mouse model, and drug sensitivity to doxorubicin and cisplatin. ❋ PLoS ONE (2010)
On the other hand, for those ncRNAs acting at their site of production, overexpressing them cannot recapitulate their normal function. ❋ Francesca De Santa Et Al. (2010)
To test this hypothesis, we injected the carcinogen 20-methylcholanthrene in the brain of transgenic mice overexpressing the mutant forms of amyloid precursor protein (APP) and presenilin 1 (PS1), as a model of AD, and their wild-type (WT) littermates. ❋ J Serrano (2010)
There is a modest increase in cell migration in cell lines overexpressing Overexpression of miR-30a or -191 does not lead to an alteration in cell cycle, proliferation, xenograft formation, and chemosensitivity of A549 and BEAS-2B cell lines. ❋ PLoS ONE (2010)
Plants overexpressing the cell cycle inhibitor KRP2 have been shown to undergo compensation during the proliferation phase; however, the mechanism of compensation is unknown ❋ Adrienne H. K. Roeder Et Al. (2010)
The research team led by Dr. Suthiphongchai T from Mahidol University used two CCA cell lines overexpressing Met, KKU-M213 and HuCCA-1, to study the role of Met in CCA invasion by activating the Met pathway with HGF. ❋ PhysOrg Team (2010)
"We challenged the aromatase-overexpressing cells with either the wild-type or the low forms of cyclin E and then treated them with the CDK2 inhibitor roscovitine," Keyomarsi said. ❋ Editors (2010)
In attempts to identify such master genes, several transgenic mouse models overexpressing individual candidate genes in distinct systems have been developed in other laboratories. ❋ Unknown (2010)
