Chinese officials have disputed the FDA's finding that the contaminant was a substance called oversulfated chondroitin sulfate. ❋ Unknown (2010)
An FDA task force that included drug-industry researchers said the adulterant was oversulfated chondroitin sulfate, a substance that increases the potency of heparin and makes it more valuable. ❋ Alicia Mundy (2011)
Baxter tests on the Delaware incidents didn't detect a contaminant found in last year's heparin-illness outbreak, oversulfated chondroitin sulfate. ❋ Unknown (2009)
But both the U.S. and Chinese drug agencies said they were investigating how the oversulfated chondroitin sulfate, which does not occur naturally, got into the heparin batches. ❋ Jan (2008)
"We presume it is the same contaminant," oversulfated chondroitin sulfate, as found in batches of heparin in the U.S., "but it has yet to be definitively confirmed," he said. ❋ Jeanne Whalen, Thomas M. Burton (2008)
Earlier this week, the U.S. Food and Drug Administration identified the contaminant in heparin batches from a Chinese supplier to U.S. pharmaceuticals company Baxter International Inc. as oversulfated chondroitin sulfate. ❋ Jan (2008)
The FDA has said it doesn't yet know how or when the contaminated ingredient, oversulfated chondroitin sulfate, was put into the supply. ❋ Unknown (2008)
Last month, the FDA said some of the heparin contained oversulfated chondroitin sulfate, an altered version of chondroitin sulfate that is used as a dietary supplement and is typically made from animal cartilage. ❋ Unknown (2008)
The contaminant – oversulfated-chondroitin sulfate – is much more plentiful in the animal, but isn't approved for medical use because it can cause severe allergic reactions in humans. ❋ Unknown (2008)
According to the guidance document, contamination involving the chemical at issue -- oversulfated chondroitin sulfate OSCS -- appears intentional to save costs. ❋ Unknown (2012)
FDA has identified a contaminant in the heparin, an oversulfated chondroitin sulfate, that may have led to the adverse events. ❋ Unknown (2010)
Some Chinese slaughterhouses had mixed "oversulfated chondroitin sulfate" into the pig intestines that were used as the raw material for the blood thinner heparin. ❋ Unknown (2010)
Background There is an urgent need to determine whether oversulfated chondroitin sulfate (OSCS), a compound contaminating heparin supplies worldwide, is the cause of the severe anaphylactoid reactions that have occurred after intravenous heparin administration in the United States and Germany. ❋ Unknown (2010)
Although the FDA has never officially been able to conclude how contaminated heparin made its way into the US, its best guess is that Chinese suppliers used oversulfated chondroitin sulfate a compound made from animal cartilage that is less expensive to produce than heparin itself which is derived from pig intestines. ❋ Unknown (2010)
The adverse reactions that ensued were later linked to specific vials of heparin that were adulterated with oversulfated chondroitin sulfate, apparently added deliberately to crude heparin in China at some stage in the production process to increase profits. ❋ Unknown (2009)
