P53

Fruit flies live significantly longer when the activity of the protein p53 is reduced in just 14 insulin-producing cells in their brains, new Brown University research shows. ❋ Unknown (2007)

DNA injury, protein p53 is phosphorylated and can no longer bind to its E3 enzyme. ❋ Unknown (2004)

Indeed, p53 is so important that when it fails, cancer often results. ❋ Unknown (2007)

Scientists continue to mine for details of what goes wrong when p53 is defective and cannot perform its tumor-fighting duties. ❋ Unknown (2007)

On the other extreme, having the perfect model of p53 in other words, an aggressive one means that you increase the risk of death from frailty. ❋ MEHMET C. OZ (2007)

The amount of protein p53 in a normal cell is low in consequence of continual production and breakdown. ❋ Unknown (2004)

The virus avoids the protein p53 control function through one of its proteins activating and changing the recognition pattern of a certain cellular E3 enzyme, E6-AP, which is tricked into ubiquitinating the protein p53, which is totally destroyed. ❋ Unknown (2004)

Protein p53 has been dubbed "the guardian of the genome" and it is a tumour-suppressor gene. ❋ Unknown (2004)

Protein p53 acts as a transcription factor, i.e. a protein that controls the expression of a certain gene. ❋ Unknown (2004)

Protein p53 binds to and controls genes that regulate DNA repair and programmed cell death. ❋ Unknown (2004)

Raised levels of protein p53 lead first to interruption of the cell cycle to allow time for repair of DNA damage. ❋ Unknown (2004)

Levine was famous for his simultaneous discovery with David Lane of the University of Dundee in 1979 of a cancer “causing” gene called p53. ❋ Martin A. Nowak (2011)

Another extraordinary discovery in the medical community is that a gene called p53 is a cell's primary defensive weapon against the malignant growth of cancerous cells that can grow without check and move from one organ to another until the health of the organism is destroyed. ❋ Unknown (2009)

Another extraordinary discovery in the medical community is that a gene called p53 is a cell's primary defensive weapon against the malignant growth of cancerous cells that can grow without check, and move from one organ to another until the health of the organism is destroyed. ❋ Unknown (2009)

They also piled up fewer mutations in a gene called p53 -- a gene that, when mutated, can cause skin cancer. ❋ Unknown (2008)

It turns out that a gene called p53 -- the gene whose useless, mutant form the luckless family passed from parent to child through the generations -- may be that switch. ❋ Unknown (2008)

An enzyme called p53 has the enormous job of regulating the timetable for cell division in normal cells. ❋ Joyce Whiteley Hawkes (2006)

The breakdown is regulated through ubiquitination and the E3 enzyme responsible forms a complex with protein p53. ❋ Unknown (2004)

Gotta [initiate] order p53 before this [tumor] [dooms] us all ! ❋ Micronomicon (2022)