Palmitoylation

Here, we discuss the regulatory mechanisms for dynamic protein palmitoylation and the emerging roles of protein palmitoylation in various aspects of pathophysiology, including neuronal development and synaptic plasticity. ❋ Yuko Fukata (2010)

Results showed that the NMDA receptor undergoes "dual palmitoylation," in two different regions, each of which plays a distinct role in controlling the fate of the receptor in neurons. ❋ Snowcrash (2010)

(Asp-His-His-Cys) protein family - and the development of new proteomic and imaging methods have accelerated palmitoylation analysis. ❋ Yuko Fukata (2010)

The reversible nature of palmitoylation provides a potential general mechanism for protein shuttling between intracellular compartments. ❋ Yuko Fukata (2010)

"If we could shift the balance of the palmitoylation, then perhaps we could affect and enhance learning and memory." ❋ Snowcrash (2010)

Protein palmitoylation, a classical and common lipid modification, regulates diverse aspects of neuronal protein trafficking and function. ❋ Yuko Fukata (2010)

The researchers suspect that if palmitoylation fails, the result would be learning and memory impairment because if NMDA receptors don't make their way to the synapses - the specialized contact points between cells across which chemical messages flow - then communication between neurons is compromised. ❋ Snowcrash (2010)

Figure 4: Downregulation of APT1 increases the steady-state palmitoylation level of Ras. ❋ Frank J Dekker (2010)

Protein palmitoylation, the most common lipid modification with the 16-carbon fatty acid palmitate, provides an important mechanism for regulating synaptic proteins in neurons. ❋ Unknown (2009)

When synaptic activity decreases, DHHC2 translocates to the synaptic site to facilitate palmitoylation of synaptic proteins to keep synaptic activity at a constant level. ❋ Unknown (2009)

The most frequently acylated residues within proteins are lysines (as in histone N-acetylation) and cysteines (as in protein S-palmitoylation); serines seem to be seldom acylated. ❋ Unknown (2009)

Kawasaki K, Ernst RK, Miller SI (2004) Deacylation and palmitoylation of lipid A by Salmonellae outer membrane enzymes modulate host signaling through Toll-like receptor 4. ❋ Unknown (2009)