Pentameric

Turns out that it's not the chocolate candy per se that has anticancer properties: The Lombardi Comprehensive Cancer Center at Georgetown University finds that it's an ingredient in cocoa, from which chocolate is made, called pentameric procyanidin. ❋ Unknown (2008)

Found in cocoa, pentameric procyandin turns off proteins that likely spur the out-of-control division of cancer cells. ❋ Unknown (2005)

The normal pentamer to monomer ratio is 10: 1 and it has been determined that mutations that destabilise the pentamer increase the active monomer concentration inhibiting SERCA2a by altering the dissociation constant between the monomeric and pentameric forms of PLN causing inhibition by mass action ❋ Parveen Sharma Et Al. (2010)

PLN exists in an inhibitory monomeric form and as a less inhibitory or inactive pentameric form ❋ Parveen Sharma Et Al. (2010)

WT PLN, and the finding in this study that PLN RΔ14 is not recovered by COP I mediated retrograde transport and has becomes localized at the plasma membrane offers a mechanism by which the concentration of PLN is reduced in the ER and a possible explanation for the destabilisation of the pentameric form of PLN. ❋ Parveen Sharma Et Al. (2010)

Previously, it was demonstrated that PLN RΔ14 mutation causes superinhibition of SERCA2a and that the mutation causes disruption in the stability of its pentameric form ❋ Parveen Sharma Et Al. (2010)

A feature of exported proteins is a pentameric motif (RxLxE/Q/D) that is a substrate for an unknown protease. ❋ Justin A. Boddey (2010)

Interestingly, FocA has a pore (black circle) in the centre of its pentameric assembly and an axial passage ❋ Unknown (2009)

Monk R, Taylor AL, Ozbek S, Fascetti N, et al. (2003) Characterisation of Drosophila thrombospondin defines an early origin of pentameric thrombospondins. ❋ Adi Tabib Et Al. (2009)

This dimer can serve as the core for the formation of pentameric and hexameric oligomers with a ring-like organization. ❋ Unknown (2008)

Interestingly although mutant and partnering wild type subunits could be coimmunoprecipitated, analytic centrifugation studies demonstrated decreased formation of pentameric receptors, suggesting that this residue played an important role in later steps of subunit oligomerization. ❋ W.-y. Lo (2008)