Perforin

Word PERFORIN
Character 8
Hyphenation N/A
Pronunciations N/A

Definitions and meanings of "Perforin"

What do we mean by perforin?

A protein in killer cells and natural killer cells that causes lysis of target cells on contact. noun

A cytolytic protein found in natural killer cells noun

A cytolytic protein found in natural killer cells.

Synonyms and Antonyms for Perforin

  • Synonyms for perforin
  • Perforin synonyms not found!!!
  • Antonyms for perforin
  • Perforin antonyms not found!

The word "perforin" in example sentences

To date, five mutations in genes coding for proteins involved in cytotoxicity of lymphocytes, namely perforin (causing FHL2), Munc13-4 ❋ Claudia A. Nold-Petry Et Al. (2010)

T-cells and killer cells release a molecule called perforin which creates small holes in the cell membrane. ❋ Unknown (2008)

Our previous studies suggest that several effector mechanisms, such as perforin, granzymes, or complements, may be involved in the killing of cancer cells. ❋ Anne Sanders (2010)

Twenty-eight gene models were identified that encode MAC- perforin domains, but none of these had the additional domains expected for terminal complement factors C6 through C9. ❋ Unknown (2006)

Instead, these are members of a novel and very interesting gene family with perforin-like structure. ❋ Unknown (2006)

Individuals heterozygous for perforin mutations have previously been studied regarding the activity of their NK cells ❋ Claudia A. Nold-Petry Et Al. (2010)

And it also releases perforin, granulysin, and a serine protease which called geanzyme. ❋ Unknown (2010)

Recent studies have further advanced the understanding of the link between the perforin defect and the cytokine storm of acute HLH, the latter of which ultimately causes the rapidly progressive multi-organ failure. ❋ Unknown (2010)

+ T-cells from patients with perforin-associated FHL fail to kill infected cells, these killer cells continue to activate macrophages and to deliver proliferation signals to T-cells. ❋ Unknown (2010)

The association of mutations in the perforin gene with the disease ❋ Claudia A. Nold-Petry Et Al. (2010)

These included Pen5, CD8α, perforin and granzyme-B, which were expressed mainly on CD56 dim cells, independently of NKG2A expression. ❋ Vivien Béziat Et Al. (2010)

Then the T-Cell secretes perforin which punches holes in the cell membrane allowing the cytoplasm to ooze out. ❋ Unknown (2010)

Despite the previously known roles of perforin, superoxide or nitric oxide in the effector mechanisms of innate immune responses, these effector mechanisms were not required for cancer-resistance in SR/CR mice. ❋ Anne Sanders (2010)

This was tested by cross breeding SR/CR mice into the individual genetic knockout backgrounds of perforin (Prf -/-), superoxide ❋ Anne Sanders (2010)

The perforin and granulysin are cytotoxins, they form pores in the target cell's plasma membrane causing ions and water to flow into the target cell that make the cell expand and eventually undergo lysis. ❋ Unknown (2010)

Cross Reference for Perforin

  • Perforin cross reference not found!

What does perforin mean?

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