It also helps protect the brain from the damaging effects of another type of reactive substance called peroxynitrite. ❋ M.D. Scott Mendelson (2011)
Increased concentrations of nitric oxide interact with oxygen-free radicals, resulting in the production of a superpotent free radical called peroxynitrite. ❋ M.D. Nicholas Perricone (2010)
How well does freeze-dried acai scavenge other free radicals such as peroxynitrite (NORAC), hydroxyl (HORAC), and superoxide anion (SORAC)? ❋ Unknown (2008)
Conversely, peroxynitrite generation requires equimolar concentrations of O ❋ Alfredo Csibi Et Al. (2010)
Arnal JF, Rami J, Michel JB (1998) Angiotensin II stimulates the production of NO and peroxynitrite in endothelial cells. ❋ Alfredo Csibi Et Al. (2010)
Szabo C (2006) Role of peroxynitrite in the pathogenesis of cardiovascular complications of diabetes. ❋ Alfredo Csibi Et Al. (2010)
Duplain H, Sartori C, Dessen P, Jayet PY, Schwab M, et al. (2008) Stimulation of peroxynitrite catalysis improves insulin sensitivity in high fat diet-fed mice. ❋ Alfredo Csibi Et Al. (2010)
Beckman JS, Koppenol WH (1996) Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. ❋ Alfredo Csibi Et Al. (2010)
ONOO − which can affect DNA, lipids and proteins Interestingly, Ang II has been shown to stimulate the generation of peroxynitrite ❋ Alfredo Csibi Et Al. (2010)
Importantly, peroxynitrite and high level of NO irreversibly inactivates mitochondrial complex I activity by tyrosine nitration, ❋ Dong-Young Choi Et Al. (2009)
Although association of NO with mitochondrial dysfunction in PD is unclear, NO and its metabolite, peroxynitrite can compromise mitochondrial biomolecules to induce impairment in mitochondrial respiration. ❋ Dong-Young Choi Et Al. (2009)
Przedborski S, Naini AB, Jackson-Lewis V, Trifiletti RR, et al. (1998) Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyri dine (MPTP). ❋ Dong-Young Choi Et Al. (2009)
Borutaite V (2004) Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols. ❋ Dong-Young Choi Et Al. (2009)
The gaseous molecule released at extramitochondrial sites can diffuse into the mitochondria and react with mitochondria-derived superoxide anion to form peroxynitrite, which accounts for much of the disruption of mitochondrial function ❋ Dong-Young Choi Et Al. (2009)
It has been documented that NO and its metabolite peroxynitrite inhibit mitochondrial respiration via S-nitrosylation and nitration of complex I, respectively ❋ Dong-Young Choi Et Al. (2009)
