Phagosome

Biology (IPBS) in Toulouse joined forces to systematically search for mycobacterial genes that block phagosome maturation. ❋ Unknown (2010)

TRPV2 was recruited to the nascent phagosome and depolarized the plasma membrane. ❋ Tiffany M Link (2010)

Based on the results, it was hypothesized that the phagosome environment and vacuole membrane of the wild-type bacterium might differ from the mutant. ❋ Unknown (2010)

The team identified ten distinct mutants, only one of which had previously been shown to play a part in phagosome maturation arrest. ❋ Unknown (2010)

Moreover, a Mon1-Ccz1 complex (but not either protein alone) could bind Rab7 and could also influence Rab7 activation, suggesting Mon1-Ccz1 as an important link in progression from the Rab5-positive stage to the Rab7-positive stage of phagosome maturation. ❋ Jason M. Kinchen (2010)

The environment in the phagosome of macrophages infected with the mutant differed from the environment of vacuoles with M. hominissuis wild-type in the concentration of zinc, manganese, calcium and potassium. ❋ Unknown (2010)

Structural Biology (IPBS) in Toulouse joined forces to systematically search for mycobacterial genes that block phagosome maturation. ❋ Unknown (2010)

The mammalian orthologues of SAND-1, namely Mon1a and Mon1b, were similarly required for phagosome maturation. ❋ Jason M. Kinchen (2010)

"High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling", PLoS Pathogens ❋ Unknown (2010)

Urease activity which was shown to be critical for M. tuberculosis survival in phagosome is dependent on Nickel, while Vitamin B12 biosynthesis which is a Cobalt dependent process is important for ❋ Gunjan Arora Et Al. (2010)

This mutant, in contrast to the wild-type bacterium, was shown both to have impaired the ability to replicate within macrophages and to have prevented phagosome/lysosome fusion. ❋ Unknown (2010)

M. tuberculosis is taken into phagosomes but it somehow blocks phagosome maturation, and hence survives. ❋ Unknown (2010)

Gavrilin MA, Bouakl IJ, Knatz NL, Duncan MD, Hall MW, et al. (2006) Internalization and phagosome escape required for Francisella to induce human monocyte IL-1beta processing and release. ❋ Ekaterina Zakharova Et Al. (2010)

man, [Ty] wont stop talking shit [about me], what a [phagosome]. ❋ XxjkjayxX (2008)