Postcapillary

We hypothesized that iron deposition and increased alveolar capillaries, the findings often seen in postcapillary PH, might predict the presence of clinical PH, independent of the severity of fibrosis or ventilatory dysfunction in IPF patients. ❋ Kyung-Hee Kim (2010)

Remodeling of postcapillary pulmonary vessels has been reported in the nonfibrotic areas of explanted lungs from IPF patients. ❋ Kyung-Hee Kim (2010)

Histamine Endogenous Vasoactive Amine • Mediates the increase in capillary permeability associated with the contraction of endothelial cells in postcapillary venules that occurs with mild injuries • Released from granules in mast cells, basophils, and platelets • Degranulation is usually a localized event in response to acute insult, therefore inflammation remains site specific Gartner and Hiatt. ❋ Unknown (2009)

Parenti A, Morbidelli L, Cui XL, Douglas JG, Hood JD, et al. (1998) Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase1/2 activation in postcapillary endothelium. ❋ Ruchika Srinivasan Et Al. (2009)

Biopsy of these lesions reveal inflammation of the small vessels, termed leukocytoclastic vasculitis, which is most prominent in postcapillary venules. ❋ Unknown (2008)