Over roughly the past decade, the CDC has been called to retrieve the remains of a man covered with smallpox lesions whose coffin was unearthed during construction near Louisville, Ky., as well as suspicious-looking scabs in a library book in New Mexico and a museum in Arkansas, says Inger Damon, chief of the CDC's poxvirus and rabies branch. ❋ Betsy McKay (2011)
The smallpox vaccine is made using a poxvirus that infects cows (cowpox or vaccinia). ❋ Unknown (2008)
Other vaccine trials using the poxvirus vaccinia as a vector to deliver live recombinant HIV (based on glycoprotein 160) have been found safe, and have stimulated partial immunity to HIV. ❋ Unknown (2004)
So far the most promising of these vaccines has been one using another poxvirus -- canarypox -- to deliver HIV recombinants (See Table 2). ❋ Unknown (2004)
To overcome this poor responsiveness, recombinant poxvirus vectors, including vaccinia, fowlpox and modified vaccinia Ankara (MVA), can be genetically engineered to express one or more tumor-associated antigens to greatly enhance the immune system's ability to recognize and destroy cancer cells bearing any of the targeted antigens. ® and CV-301 are prime-boost vaccines, sequentially combining two different poxviruses (vaccinia and fowlpox). ❋ Unknown (2011)
CV-301 originates from the same poxvirus technology platform as PROSTVAC ❋ Unknown (2011)
British research has found that the vaccinia poxvirus spreads infection by jumping from one cell to another before it finds an uninfected cell. ❋ Unknown (2010)
The attachment of a poxvirus particle to a cell triggers a multitude of incompletely understood signaling events inside the cell. ❋ Unknown (2010)
The discovery could also lead to inhibitors against the most serious and infectious parts of the virus, which will be useful for combating a poxvirus infection, Deng said. ❋ Unknown (2009)
They solved a three-dimensional crystal structure of a poxvirus protein in the act of disarming the IL-18. ❋ Unknown (2009)
As there is currently no medication for poxvirus-caused diseases, this research could aid national and international security efforts against potential poxvirus use as bioterrorism. ❋ Unknown (2009)
"In the future, we can design a drug to stop the poxvirus from blocking the IL-18 protein." ❋ Unknown (2009)
Rhodes D, Bushman F (2000) Rapid microtiter assays for poxvirus topoisomerase, mammalian type IB topoisomerase and HIV-1 integrase: application to inhibitor isolation. ❋ Unknown (2009)
"It (the discovery) helps us understand how poxvirus causes disease by evading the immune response," Deng said. ❋ Unknown (2009)
If this breakthrough is made, it will help advance the finding of the structure of the poxvirus protein, which could lead to the development of medication and other items necessary to fight poxviruses, Krumm said. ❋ Unknown (2009)
OSU biochemistry researchers make a poxvirus breakthrough ❋ Unknown (2009)
They uncovered the structure of a poxvirus protein in complex with the immune system, which revealed why the human immune system is unable to fight the virus, Deng said. ❋ Unknown (2009)
