Procarbazine

This modified regimen contained less cyclophosphamide and procarbazine, agents known to impair fertility. ❋ Unknown (2010)

For the past decade, a modified chemotherapy regimen consisting of cyclophosphamide, vincristine, procarbazine and prednisone (COPP), together with adriamycin, bleomycin and vinblastine (ABV) has been used to treat patients with HD. ❋ Unknown (2010)

On one side of the board was a list of cytotoxic drugs—Cytoxan, vincristine, procarbazine, methotrexate. ❋ Siddhartha Mukherjee (2010)

Methotrexate was substituted with a more powerful agent, procarbazine, and the duration of treatment was lengthened from two and a half months to six months. ❋ Siddhartha Mukherjee (2010)

Alliance says that combined sales of ImmuCyst, Gelclair, and procarbazine represent some 40% of Cambridge Labs total sales in 2009. ❋ Unknown (2010)

These include: ImmuCyst®, an immunotherapy for superficial bladder cancer; Gelclair®, an oral gel for managing oral mucositis in chemotherapy patients; and the Hodgkin lymphoma therapy procarbazine. ❋ Unknown (2010)

This trial compared the following regimens: doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) for 6 to 8 months, mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) for 6 to 8 months, and MOPP alternating with ABVD for 12 months. 1 The trial was limited to patients with advanced disease (clinical stages III and IV). ❋ Canellos, G. P., Niedzwiecki, D., Johnson, J. L. (2009)

However, the COG trial with 401 patients enrolled, showed that a thioguanine, procarbazine, lomustine and vincristine (TPCV) regimen was more effective than the CV regimen and resulted in a five-year event-free survival rate of nearly ❋ Unknown (2008)

The study of 401 patients found that a regimen of thioguanine, procarbazine, lomustine and vincristine (TPCV) was more effective than a carboplatin and vincristine (VC) regimen and achieved a 5-year, event-free survival rate of almost 50 percent. ❋ Unknown (2008)