Replicon

Word REPLICON
Character 8
Hyphenation N/A
Pronunciations N/A

Definitions and meanings of "Replicon"

What do we mean by replicon?

A genetic element that undergoes replication as an autonomous unit. noun

A DNA molecule or a region of DNA that replicates as an individual unit. A replicon may be, for instance, a chromosome, a plasmid or a phage. noun

A DNA molecule or a region of DNA that replicates as an individual unit. A replicon may be, for instance, a chromosome, a plasmid or a phage.

Synonyms and Antonyms for Replicon

  • Synonyms for replicon
  • Replicon synonyms not found!!!
  • Antonyms for replicon
  • Replicon antonyms not found!

The word "replicon" in example sentences

Tucker and a panel of experts explained that the first medication on trial was the AlphaVax replicon Vector (ArV) clade C ❋ Unknown (2003)

The trials would assess the AlphaVax replicon Vector (ArV) candidate vaccine, a technology that used artificial virus-like particles containing parts of a strain of Venezuelan equine encephalitis, and a gene from a South African HIV strain, to deliver the vaccine to the immune system. ❋ Unknown (2003)

Analysis of the inhibition of the HCV replicon by SOFA-HDV ribozymes. ❋ Michel V. L�vesque Et Al. (2010)

The cleavage of the HCV (−) strand by all of these SOFA-HDV ribozymes was then accessed using both the replicon and the lentivirus systems as described above. ❋ Michel V. L�vesque Et Al. (2010)

In summary, some SOFA-HDV ribozymes exhibited sufficiently high cleavage levels of the IRES that they significantly reduced the luciferase activity; however, the observed level of replicon inhibition was never high enough to warrant further development of the SOFA-HDV ribozyme as an antiviral drug against HCV. ❋ Michel V. L�vesque Et Al. (2010)

Specifically, replicon containing cells may already possess membranous alterations due to replication complexes. ❋ Michel V. L�vesque Et Al. (2010)

This report shows that targeting the HCV replicon system using SOFA-HDV ribozymes was not really productive, even when great attention was devoted towards optimizing their design. ❋ Michel V. L�vesque Et Al. (2010)

Jessica Lee jessica. lee@replicon.com www. replicon.com ❋ Unknown (2010)

Randall G, Grakoui A, Rice CM (2003) Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs. ❋ Michel V. L�vesque Et Al. (2010)

Similar replicon systems were used in many other studies in order to screen various nucleic acid-based approaches including siRNA ❋ Michel V. L�vesque Et Al. (2010)

The authors would like to thank R. Bartenschlager for kindly providing the bicistronic HCV replicon. ❋ Michel V. L�vesque Et Al. (2010)

Huh-7 cells containing the bicistronic replicon were seeded in 24 well plates at a confluence of 5×10 ❋ Michel V. L�vesque Et Al. (2010)

From that point and until the end of the experiment, Huh-7 cells containing the replicon were never in contact with media containing G-418 or antibiotic. ❋ Michel V. L�vesque Et Al. (2010)

Vrolijk JM, Kaul A, Hansen BE, Lohmann V, Haagmans BL, et al. (2003) A replicon-based bioassay for the measurement of interferons in patients with chronic hepatitis C. J Virol Methods 110: 201-209. ❋ Michel V. L�vesque Et Al. (2010)

The potential abilites of all SOFA-HDV ribozymes to inhibit an HCV replicon were tested. ❋ Michel V. L�vesque Et Al. (2010)

The ability of the resulting SOFA-HDV ribozymes to inhibit HCV replication was further examined using a luciferase-based replicon. ❋ Michel V. L�vesque Et Al. (2010)

It is important to note that during an experiment neither G-418 nor antibiotic were used in order to reduce interference with cell transduction as well as to avoid the positive selection of HCV replicon containing cells while measuring the effect of the SOFA-HDV ribozymes. ❋ Michel V. L�vesque Et Al. (2010)

The use of different lentivirus concentrations did not result in improved inhibition of the replicon. ❋ Michel V. L�vesque Et Al. (2010)

One potential explanation for the limited cleavage activity might be the bicistronic replicon system used to screen the ribozyme in cellulo, although it has been used successfully in many studies ❋ Michel V. L�vesque Et Al. (2010)

The expression of all chimeric tRNAVal: SOFA-HDV ribozymes was confirmed at the time of the replicon inhibition assay (i.e. 48 h post transduction, data not shown). ❋ Michel V. L�vesque Et Al. (2010)

Cross Reference for Replicon

  • Replicon cross reference not found!

What does replicon mean?

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