The possibility that the drug could reverse the reserpine effect, Kline said, “immediately led me to speculate whether this was the psychic energizer for which we had all been looking.” ❋ Gary Greenberg (2010)
MAOI drugs like iproniazid, on the other hand, countered the reserpine effect and raised levels of norepinephrine. ❋ Gary Greenberg (2010)
In 1956, Kline heard that scientists had given iproniazid along with reserpine to lab animals, which, far from being sedated, had become hyperactive. ❋ Gary Greenberg (2010)
Some common medications, such as phenothiazines, imipramine, methyldopa, and reserpine, will also raise prolactin levels, as will excessive stress. ❋ Mark L. Fuerst (2010)
The trial was a success, but the drug was reserpine, which, according to the theory should have been anything but an antidepressant. ❋ Gary Greenberg (2010)
Given what John Gaddum and other researchers were saying about LSD and serotonin, Kline and other scientists speculated that reserpine was increasing serotonin levels in the brain. ❋ Gary Greenberg (2010)
The reserpine study was simply ignored, probably because it ran counter to the increasingly prevailing wisdom. ❋ Gary Greenberg (2010)
In 1965, he reviewed all the evidence—the reserpine research, the clinical trials with drugs like imipramine and iproniazid, the studies showing evidence of increased catecholamines in the blood and urine of people taking antidepressants, the discoveries of enzyme and reuptake inhibition—and concluded, “There is good evidence to support the thesis that the antidepressant effects of both the monoamine oxidase inhibitors and the imipramine-like drugs are mediated through the catecholamines.” ❋ Gary Greenberg (2010)
The reserpine experiments, the ones that showed less serotonin activity in the brains of animals that had suffered a reserpine-induced “depression,” gave credence to this emerging hypothesis about how iproniazid worked, and, in the bargain, to the serotonin theory of mental illness. ❋ Gary Greenberg (2010)
Moreover the suicidal and akathisia side effects that blemished the antidepressant Prozac were revealed -- but ignored -- in case reports of the antihypertensive drug, reserpine. ❋ Unknown (2008)
Before World War II, when federal support for scientific research was slight, the Research Corporation provided much-needed funds for Ernest Lawrence's development of the cyclotron, R.H. Goddard's experiments with rockets, the processes for volume production of vitamins A and B1, and some of Robert Burns Woodward's early organic syntheses of such complex organic molecules as the drug reserpine. ❋ Unknown (2008)
The medicalization of depression dates to a "chemical imbalance" theory of the late 1950s, when some patients taking the anti-hypertensive drug reserpine got depressed. ❋ Unknown (2008)
Carlsson used a naturally occurring substance, reserpine, which depletes the storage of several synaptic transmitters. ❋ Unknown (2000)
Carlsson, therefore, gave L-DOPA to the reserpine-treated animals. ❋ Unknown (2000)
By giving the drug reserpine to animals he emptied the stores of dopamine in their brains. ❋ Unknown (2000)
He then used a naturally occurring substance, reserpine, which empties the dopamine from the nerves, and found that the animals lost their ability to move. ❋ Unknown (2000)
These medications, including diuretics (hydrochlorthiazide), beta blockers (Corgard, Lopressor, Tenormin), and the old-fashioned medications such as reserpine and methyldopa, may reduce libido and cause sexual dysfunction. ❋ M.D. Valerie Davis Raskin (2002)
Arvid Carlsson realized that the symptoms caused by reserpine were similar to the syndrome of Parkinson's disease. ❋ Unknown (2000)
