Retigabine

Word RETIGABINE
Character 10
Hyphenation N/A
Pronunciations N/A

Definitions and meanings of "Retigabine"

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Synonyms and Antonyms for Retigabine

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The word "retigabine" in example sentences

The product, known as retigabine outside the U.S., also is under review by the European Medicines Agency. ❋ Unknown (2010)

The drug, known as retigabine outside the U.S., also is under review by the European Medicines Agency. ❋ Unknown (2010)

The company is working with GlaxoSmithKline to bring the epilepsy drug retigabine to market, while preparing to find a partner to shepherd the Hepatitis C treatment taribivirin through late-stage development. ❋ Unknown (2009)

GlaxoSmithKline PLC said it is teaming up with California-based Valeant Pharmaceuticals International to develop and market an experimental epilepsy drug, retigabine, in a deal that could be worth up to $820 million. ❋ Unknown (2008)

GlaxoSmithKline will make an upfront payment of $125 million to Valeant and will pay up to $545 million as retigabine reaches certain development and marketing milestones. ❋ Unknown (2008)

"We believe that retigabine could potentially play a significant role in improving the management of epilepsy and is a welcome addition to GlaxoSmithKline's portfolio," Europe's largest drug maker by sales said in a statement. ❋ Unknown (2008)

The Aliso Viejo, Calif., company said a Phase III trial of its retigabine epilepsy treatment demonstrated positive results on its primary efficacy endpoints. ❋ Unknown (2008)

The new drug, retigabine, acts through a novel mechanism, different from the existing antiepileptic drugs. ❋ Unknown (2007)

Agency's Committee for Medicinal Products for Human Use has issued a positive opinion, recommending marketing authorisation for Trobalt (retigabine) as an adjunctive (add-on) ❋ Unknown (2011)

So even if retigabine reaches the market, it may have trouble gaining much share from generic versions of drugs like Keppra, which has few side effects. ❋ Bill Alpert (2009)

A large number of test subjects withdrew from the retigabine trial because of side effects. ❋ Bill Alpert (2009)

Main MJ, Cryan JE, Dupere JR, Cox B, Clare JJ, et al. (2000) Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine. ❋ Noa Regev Et Al. (2009)

But with the Aliso Viejo, Calif. -based company now valued at $3 billion, a 50% premium to other specialty drug makers (see table at left), investors may be overestimating the potential for the epilepsy drug, retigabine, to offset waning royalties from Valeant's most important product, the antiviral drug ribavirin. ❋ Bill Alpert (2009)

But as ribavirin royalties tail off and other big sellers go generic, Valeant may have a hole in its income statement too large for retigabine to fill, even if the proposed drug gets approval to enter the crowded epilepsy-drug market. ❋ Bill Alpert (2009)

The company's great hope is the innovative anti-epilepsy drug retigabine. ❋ Bill Alpert (2009)

Clinical trials showed that retigabine reduced seizures in such patients. ❋ Bill Alpert (2009)

If retigabine can't sustain Valeant's premium stock multiple, the shares could drop by a third. ❋ Bill Alpert (2009)

"I personally think it's going to be a success," says Michael Rogawski, neurology chairman at the University of California/Davis School of Medicine, who has followed retigabine since his days as a researcher at the National Institutes of Health. ❋ Bill Alpert (2009)

At all three doses tested, retigabine demonstrated statistically significant ❋ Unknown (2008)

In RESTORE 1, the median reduction in 28-day total partial seizure frequency from baseline to the end of the double-blind period (the FDA primary efficacy endpoint) in the intent-to-treat (ITT) population was 44. 3\% (n = 151) and 17. 5\% (n = 150) in the retigabine 1200 mg arm and placebo arm of the trial, respectively. ❋ Unknown (2008)

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