Ribonuclear

The newest candidate identified by Valente and Goff is known as N-86-hnRNPU, as it was derived from the N, or amino, end of an 86 amino acid fragment of the normal cell protein, heterogeneous nuclear ribonuclear protein U. ❋ Unknown (2007)

Often, women with nonspecific lupuslike symptoms who do not fulfill the criteria for SLE will have high levels of antibodies to ribonuclear protein. ❋ ROBIN DIBNER (1994)

Moreover, NNK would activate heterogeneous nuclear ribonuclear protein U (hnRNP-U) to allow the translocation of the βTrCP proteins from the nucleus to the cytoplasm, inducing the accumulation of the DNMT1 proteins. ❋ Unknown (2010)

Experimental data shows the ribonuclear complexes sequester similar sets of proteins in the nucleus, apparently causing misregulation of normal cellular processes, in particular RNA splicing ❋ Morgan A. Sammons Et Al. (2010)

Ferron et al. now report that two proteins, stargazin-like γ7 protein and heterogeneous ribonuclear protein A2 (hnRNP A2, previously implicated in stabilizing, trafficking, and enhancing translation of specific mRNAs), interact to control expression of the voltage-dependent calcium channel Cav2. 2 by regulating its mRNA stability. hnRNP A2 binds to Cav2. 2 mRNA, increasing mRNA stability and protein expression. γ7 binds to hnRNP A2, disrupting its interaction with Cav2. 2 mRNA, which results in increased degradation of Cav2. 2 mRNA (and other mRNAs to which hnRNP A2 binds) and decreased protein expression. ❋ Unknown (2008)

Ferron et al. now report that two proteins, stargazin-like γ7 protein and heterogeneous ribonuclear protein A2 (hnRNP A2, previously implicated in stabilizing, trafficking, and enhancing translation of specific mRNAs), interact to control expression of the voltage-dependent calcium channel Ca v2. 2 by regulating its mRNA stability. hnRNP A2 binds to Ca v2. 2 mRNA, increasing mRNA stability and protein expression. γ7 binds to hnRNP A2, disrupting its interaction with Ca v2. 2 mRNA, which results in increased degradation of Ca v2. 2 mRNA (and other mRNAs to which hnRNP A2 binds) and decreased protein expression. ❋ Unknown (2008)