Roscovitine

With one drug - roscovitine, currently in clinical trials for an unrelated ailment - a regular heartbeat was restored. ❋ Unknown (2011)

(B) Endogenous raptor is phosphorylated on Thr706 in synchronized cells undergoing mitosis, and this phosphorylation is blocked by the CDK inhibitor roscovitine. ❋ Dana M. Gwinn Et Al. (2010)

The second article was entitled "R-roscovitine (seliciclib) affects CLL cells more strongly than combinations of fludarabine or cladribine with cyclophosphamide: Inhibition of CDK7 sensitizes leukemic cells to caspase-dependent apoptosis". ❋ Unknown (2010)

Seliciclib (CYC202 or R-roscovitine), a CDK (cyclin dependent kinase) inhibitor, is in Phase 2 studies for the treatment of lung cancer and nasopharyngeal cancer and in a Phase 1 trial in combination with sapacitabine. ❋ Unknown (2010)

Seliciclib (CYC202 or R-roscovitine), a CDK (cyclin dependent kinase) inhibitor, is in Phase 2 ❋ Unknown (2010)

"We challenged the aromatase-overexpressing cells with either the wild-type or the low forms of cyclin E and then treated them with the CDK2 inhibitor roscovitine," Keyomarsi said. ❋ Unknown (2010)

Eight to ten hours later, 2 mM thymidine was added again for 14-16 hours, cells were washed twice with PBS, then released into thymidine-free media. 50 uM roscovitine was administered for 6 hours following 16 hours nocodazole treatment in A549 cells. ❋ Dana M. Gwinn Et Al. (2010)

Nocodazole-treated mitotic cells were isolated by shake-off and, if indicated, subsequently treated with the Cdk1-inhibitor roscovitine for 30 min. ❋ Marcel A. T. M. Van Vugt Et Al. (2010)

(D) Hela cells stably expressing myc-raptor (wt or 3A) with stable knockdown of endogenous raptor were treated with nocodazole for 16 hours, then Torin1 or roscovitine were added for 4 hours. ❋ Dana M. Gwinn Et Al. (2010)

We further examined cdc2 involvement through acute treatment of nocodazole arrested cells with the cdc2 inhibitor roscovitine. ❋ Dana M. Gwinn Et Al. (2010)