Self Tolerance

Word SELF TOLERANCE
Character 14
Hyphenation N/A
Pronunciations N/A

Definitions and meanings of "Self Tolerance"

What do we mean by self tolerance?

Tolerance by the body's immune system to its own cells and tissues. noun

Here you will find one or more explanations in English for the word self-tolerance. Define self-tolerance, self-tolerance synonyms, self-tolerance pronunciation, self-tolerance translation, English dictionary definition of self-tolerance.

Synonyms and Antonyms for Self Tolerance

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The word "self-tolerance" in example sentences

T-cells are designed with an in-built safety mechanism, called self-tolerance, which normally stops them from accidentally reacting with healthy tissues. ❋ Unknown (2011)

Key contributions to cellular immunology included the discovery that T cells derived from the thymus 'helped' B cells to produce antibody, proof of the clonal selection theory, delineation of the earliest stages of T cell development in the thymus, and the nature of self-tolerance. ❋ Unknown (1997)

Morphine, however, exerted the stronger influence.5 This demonstrated a phenomenon that might be called “self-tolerance.” ❋ Kenneth Blum (1991)

It was weaker than self-tolerance, but definitely present. ❋ Kenneth Blum (1991)

This loss of self-esteem is generally transient, and when the super-ego matures and regains resiliance and flexibility, there is more self-tolerance for mistakes or shortcomings. ❋ Judith Marks Mishne (1986)

Breckon were really coming up to sit by her, she would blush to her hair, and wish to run away, and failing the force for this, would sit cold and blank to his civilities, and have to be skilfully and gradually talked back to self-respect and self-tolerance. ❋ William Dean Howells (1878)

"In trying to understand the link between this group of conditions -- autoimmunity, chronic infections and cold urticaria -- we not only identified a disease-causing mutation but uncovered a unique and fascinating genetic mechanism at the crux of allergy, immune defense and self-tolerance," Milner added. ❋ Unknown (2012)

But when self-tolerance goes wrong, self-reactions can occur that are the root cause of auto-immune diseases, such as type 1 diabetes and multiple sclerosis. ❋ Unknown (2011)

Because cancer cells are usually normal, healthy cells, which have malfunctioned in some way, self-tolerance can limit the ability of T-cells to react against, and kill, tumours. ❋ Unknown (2011)

The Major Histocompatibility Complex (MHC) are the major proteins in establishing self-tolerance, without the possibility of an animal destroyed by its own immune system. ❋ Unknown (2010)

Akiyama T, Shimo Y, Yanai H, Qin J, Ohshima D, et al. (2008) The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. ❋ Masako Osada Et Al. (2010)

These TRAs represent a pool of self-antigens, which are used to negatively select auto-reactive thymocytes to induce self-tolerance or differentiation of regulatory T cell subsets. ❋ Masako Osada Et Al. (2010)

"Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity", ❋ Unknown (2009)

Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S (2002) Stimulation of CD25 (+) CD4 (+) regulatory T cells through GITR breaks immunological self-tolerance. ❋ Guojiang Chen Et Al. (2009)

The GK/Par model illustrates the effectiveness of adaptive response to OS by β-cells to achieve self-tolerance. ❋ Unknown (2009)

+ T cell, referred to as regulatory T cells (Tregs), has an important role in controlling other immune responses, maintaining peripheral self-tolerance ❋ Karina M. Melo Et Al. (2009)

Two major mechanisms enforce self-tolerance: negative selection in the thymus and dominant tolerance in the periphery. ❋ Unknown (2009)

T cell tolerance is established in the thymus, an organ uniquely specialized to support the development of T cells and regulate their self-tolerance. ❋ Unknown (2008)

Cross Reference for Self Tolerance

  • Self Tolerance cross reference not found!

What does self tolerance mean?

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