Somatotropic

Word SOMATOTROPIC
Character 12
Hyphenation N/A
Pronunciations N/A

Definitions and meanings of "Somatotropic"

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Synonyms and Antonyms for Somatotropic

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The word "somatotropic" in example sentences

Guarente said that sirtuins bring about the effects of calorie restriction on a brain system, known as the somatotropic signaling axis, that controls growth and influences lifespan length. ❋ Unknown (2009)

Genes and Development, Guarente adds to his case by reporting that sirtuins bring about the effects of calorie restriction on a brain system, known as the somatotropic signaling axis, that controls growth and influences lifespan length. ❋ Unknown (2009)

Milk consumption and the prepubertal somatotropic axis. ❋ M.D. Mark Hyman (2009)

The normal mice showed much lower levels of circulating growth hormones, demonstrating that their somatotropic signaling system was impaired, but calorie restriction had no effect on hormone levels of mice that could not produce SIRT1. ❋ Unknown (2009)

In future work, Guarente plans to investigate the mechanism by which sirtuins regulate the somatotropic axis. ❋ Unknown (2009)

Our findings, along with results from other laboratories, firmly establish the physiological role of the somatotropic axis (GH and IGF-1) in the control of aging in mammals. ❋ Unknown (2009)

Dissecting the pathophysiological mechanism, we discovered that IGF receptors in the mammalian brain efficiently steered the development of the somatotropic axis, which in turn affected the individual growth trajectory and lifespan. ❋ Unknown (2008)

Therefore, we suspected that this somatotropic phenotype was caused by alterations in GH-regulatory neurons of the hypothalamus, i.e. arcuate nucleus GHRH neurons and anterior periventricular somatostatin (SRIH) neurons whose endings converge on the external layer of the median eminence (ME). ❋ Unknown (2008)

We conclude that the IGF-1R gene is heterosufficient with respect to neurotrophic action, but heteroinsufficient with regard to its role in regulating somatotropic plasticity. ❋ Unknown (2008)

Our results also suggest that tonic somatotropic signaling entails the risk of shortened lifespan. ❋ Unknown (2008)

Collectively, this cascade is known as the "somatotropic axis," and the authors reasoned that if the axis is ultimately controlled from the brain, then its ability to respond to resource fluctuations might be found there as well. ❋ Unknown (2008)

Therefore, the evolutionary significance of somatotropic plasticity may be that it cushions otherwise deleterious effects of selective pressure. ❋ Unknown (2008)

We showed that downregulation of somatotropic hormones postponed mortality and increased mean lifespan. ❋ Unknown (2008)

In vertebrates, these somatotropic hormones are controlled by the neuroendocrine brain. ❋ Unknown (2008)

The ME also harbors numerous tanycytes, glia specialized in IGF-I transport to the brain, that may contribute to the modulation of somatotropic signals by acting on the maturation of GHRH neurons. ❋ Unknown (2008)

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