Gamma-tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. ❋ Craig Cooper (2011)
In particular we propose that the well-known clusters of Ashkenazi genetic diseases, the sphingolipid cluster and the DNA repair cluster in particular, increase intelligence in heterozygotes. ❋ Unknown (2007)
The authors "make pretty much all of the classic mistakes in interpreting heritability," said Dr. Andrew Clark, a population geneticist at Cornell University, and the argument that the sphingolipid gene variants are associated with intelligence, he said, is "far-fetched." ❋ Steve Sailer (2005)
As to how the disease mutations might affect intelligence, the Utah researchers cite evidence that the sphingolipid disorders promote the growth and interconnection of brain cells. ❋ Steve Sailer (2005)
Unlike many speculations, it makes a testable prediction: that people who carry one of the sphingolipid or other Ashkenazic disease mutations should do better than average on I.Q. tests. ❋ Steve Sailer (2005)
Dr. Slatkin, though favoring a founder effect over all, said he agreed with the Utah team that this would not account for the cluster of sphingolipid diseases. ❋ Steve Sailer (2005)
The sphingolipid-storage diseases, Tay-Sachs, Gaucher's and Niemann-Pick, all involve extra growth and branching of the protuberances that connect nerve cells together. ❋ Steve Sailer (2005)
The company believes its patent estate provides broad, commercially significant coverage of antibodies, receptors, enzymes, or other moieties that bind to a lysolipid or a sphingolipid metabolite for diagnostic, therapeutic, or screening purposes.
Lpath has also obtained issued claims on sphingolipid targets e.g., receptors and signaling sphingolipids and methods for using such targets in drug-discovery screening efforts.
The new U.S. patent No. 7,862,812 claims methods of decreasing an immune response and treating diseases or conditions characterized by an aberrant, excessive, or undesired immune response using an antibody that inhibits a sphingolipid or sphingolipid metabolite, such as S1P.
Lpath's intellectual-property portfolio includes compositions of matter that specifically bind to sphingolipids and sphingolipid metabolites.
It was also observed that fungal GIPCs were able to inhibit T lymphocyte proliferation "in vitro", and studies regarding the importance of these molecules to fungal survival showed that many species of fungi are vulnerable to inhibitors of sphingolipid biosynthesis. ❋ Marcos Toledo (2010)
Furthermore, insights into the actions of PaCD and eukaryotic neutral CDases as an exotoxin and mediators of sphingolipid signaling are also ❋ T. Inoue (2009)
They were fascinated by talk of sickle-cells and malaria, but repulsed by similarly described interactions of sphingolipid brain enhancement / disorder. ❋ Unknown (2009)
The odds of Ashkenazi Jews having four sphingolipid storage disorders by random chance are less than 1 in 100,000, he calculated. ❋ Unknown (2009)
