One guess was that electricity inhibited excess activity in a cluster of nerves called the subthalamic nucleus STN. ❋ Michael Chorost (2011)
"Deep brain stimulation," or DBS, involves placing electrodes into a small region called the subthalamic nucleus, an area important for controlling movement. ❋ Unknown (2007)
DBS activates a part of the brain called the subthalamic nucleus, but it had been unclear which of the many cell types in the nucleus confer the therapeutic benefits that had been observed. ❋ William Harryman (2009)
Patients with Parkinson's have reduced levels of a chemical - GABA - in part of the brain known as the subthalamic nucleus. ❋ Unknown (2011)
As a result the doctors had to find another part of the brain to site the two electrodes, deciding on a small area called the subthalamic nucleus in the mid-brain region. ❋ Unknown (2011)
There was increased activity in, and increased connectivity between, two regions: the prefrontal cortex (PFC) and an area of the midbrain called the subthalamic nucleus (STN). ❋ < (2010)
The fMRI scans showed that a region of the brain known as the subthalamic nucleus (STN) was more active in the cases when the default was rejected. ❋ Unknown (2010)
"Deep brain stimulation is basically a black box," says Guoping Feng, a neurobiologist at Duke University in Durham, N.C. Scientists know that inserting an electrical probe deep into the brain and stimulating an area known as the subthalamic nucleus can help people with Parkinson's disease overcome the disorder's neurological block on movement. ❋ Unknown (2009)
Neurologix's gene transfer approach to Parkinson's disease seeks to restore GABA -- and thus improve the patient's motor control -- by inserting the GAD gene back into an area of the brain called the subthalamic nucleus, a key regulatory center for movement. ❋ Unknown (2009)
In Parkinson's disease, GABA is reduced in an area of the brain called the subthalamic nucleus, causing it to be overactive. ❋ Unknown (2009)
There was no way to shut down only the subthalamic nucleus. ❋ Michael Chorost (2011)
There was a third hypothesis: that electricity activated axons leading into the subthalamic nucleus, making it behave properly. ❋ Michael Chorost (2011)
For them, what had worked was stimulating the axons that led to the subthalamic nucleus. ❋ Michael Chorost (2011)
Years ago, scientists noticed that Parkinson's disease involved excess activity in the brain's subthalamic nucleus—a spot about the size of a pea in the basal ganglia. ❋ Melinda Beck (2012)
The therapy, which was done with local anesthesia, used a harmless, inactive virus to deliver the GAD gene into each patient's subthalamic nucleus, a key brain region involving motor function. ❋ Unknown (2011)
