You are suggesting that small RNA would assume the function performed by protein amino acyl synthetases and if we presume all the foregoing what leads you to think this mixture would evolve to produce a cell? ❋ Unknown (2010)
There is already chemical necessity between amino acids and their codons due to the aminoacyl-tRNA synthetases. ❋ Unknown (2010)
Aminoacyl-tRNA synthetases (aaRSs) are responsible for creating the pool of correctly charged aminoacyl-tRNAs that are necessary for the translation of genetic information (mRNA) by the ribosome. ❋ Unknown (2009)
If so, what is the point of the remainder of the tRNA, its 3-D shape, its chemical make-up or the synthetases themselves? ❋ Unknown (2010)
Since aminoacyl-tRNA synthetases are proteins, that necessity suffers from the chicken-and-egg problem when trying to explain the origin of translation. ❋ Unknown (2010)
Our framework fits naturally the recently proposed picture that early evolution was dominated by HGT, as evidenced by detailed phylogenetic (15), biochemical (16), and structural (17) analyses of the aminoacyl-tRNA synthetases. ❋ Unknown (2009)
Genetic code origins: tRNAs older than their synthetases? is a PNAS paper which begins with this paragraph: ❋ Unknown (2008)
Yeah, a gradual, step by step development of DNA codons, mRNA, varieties of tRNA and amino acyl tRNA synthetases, and all that on route to a genetic code - now that's something to stick in your weed pipe. ❋ Unknown (2008)
The designer could make any synthetases and thus any code desired. ❋ Unknown (2009)
"Given the results obtained thus far, further selections and tinkering will probably yield substantial improvements" molecules that come closer to having the catalytic activity of modern protein-based aminoacyl-tRNA synthetases. ❋ Unknown (2007)
Is it possible that a designer, noticing the attraction between the amino acids and their codons, and knowing that would increase the likelihood of the amino acids being the right neighborhood, designed the synthetases and tRNAs accordingly? ❋ Unknown (2009)
A signal is generated through the transcription (mRNA) of DNA (this is a very simplified version which omits detailing the many components of successful signaling i.e. promotor regions, RNA polymerases, transcription factors and more) tRNA and tRNA aminoacyl synthetases would be components involved in a translation process involving codons and anti-codons, the ribosome, the destination. ❋ Unknown (2007)
There are self-checking mechanisms identified in RNA polymerases, aminoacyl synthetases and ribosomes and the genetic code functions as a protocol. ❋ Unknown (2007)
Researchers have "tinkered" to find RNA catalysts that would mimick the function of aminoacyl-tRNA synthetases. ❋ Unknown (2007)
Bradford: Researchers have "tinkered" to find RNA catalysts that would mimick the function of aminoacyl-tRNA synthetases. ❋ Unknown (2007)
In addition if binding affinity is a gauge then the binding affinity of the active sites of aminoacyl tRNA synthetases is instructive. ❋ Unknown (2007)
