The finding provides new insight into the fundamentals of Parkinson's disease and the role of an abundant yet mysterious brain protein known as alpha-synuclein, which is believed to help brain cells communicate but may have a more sinister role in the development of neurological diseases. ❋ Unknown (2009)
It has been revealed that the Lewy body contains nitrated alpha-synuclein which is prone to [forming aggregates]. ❋ Unknown (2008)
It identified unusual forms of alpha-synuclein, a major component of Lewy bodies, which is a signature characteristic in the brain tissue of ❋ Unknown (2011)
Uversky VN, Li J, Fink AL (2001) Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. ❋ Diane Latawiec Et Al. (2010)
UC San Diego researchers say too much alpha-synuclein shuts down cell communications, helps cause dementia In diverse neurodegenerative diseases ranging from Parkinson's to Alzheimer's, researchers have long noted accumulations of ❋ Unknown (2010)
The action of dopamine on the aggregation of the unstructured alpha-synuclein (α-syn) protein may be linked to the pathogenesis of Parkinson's disease. ❋ Diane Latawiec Et Al. (2010)
Gregory A. Petsko, DPhil of Brandeis University is investigating shapes that the protein alpha-synuclein may take within cells that can lead to its aggregation into Lewy bodies, a pathological hallmark of Parkinson's disease. ❋ Unknown (2010)
Wood SJ, Steavenson S, Jiang Y, Wu GM, et al. (1999) Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation. ❋ Diane Latawiec Et Al. (2010)
With previous MJFF support Dr. Petsko demonstrated that the inhibition of enzymes that cleave alpha-synuclein in yeast and mammalian cell models prevents cell death from the protein. ❋ Unknown (2010)
Huang C, Ren G, Zhou H, Wang CC (2005) A new method for purification of recombinant human alpha-synuclein in Escherichia coli. ❋ Diane Latawiec Et Al. (2010)
Now J. Timothy Greenamyre, MD, PhD, of the University of Pittsburgh is collaborating with Dr. Li to characterize the alpha-synuclein models 'neurobehavioral deficits, neurochemical alterations, dopaminergic cell loss, neuropathology and molecular features. ❋ Unknown (2010)
Mazzulli JR, Mishizen AJ, Giasson BI, Lynch DR, Thomas SA, et al. (2006) Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates. ❋ Diane Latawiec Et Al. (2010)
The project announced today builds further on this research by studying the particular structure that makes alpha-synuclein more or less sensitive to these enzymes in order to determine whether this process can be targeted therapeutically. ❋ Unknown (2010)
In transgenic mouse models of the Lewy body variant of Alzheimer's, Parkinson's-related alpha-synuclein proteins (green) and the beta-amyloid protein plaques (red) and tau protein tangles (blue) associated with Alzheimer's ❋ Unknown (2010)
Alpha-synuclein is widely believed to play a central role in the development of Parkinson's disease. ❋ Unknown (2010)
The new data show effective silencing of the alpha-synuclein gene with an RNAi therapeutic, in a pre-clinical trial, testing the technology on a group of non-human primates. ❋ Unknown (2010)
His team successfully used bacterial artificial chromosome (BAC) technology to generate rat lines with five of the most common genetic mutations associated with PD (three alpha-synuclein lines and two LRRK2 lines). ❋ Unknown (2010)
Wypych J, Steavenson S, Louis JC, Citron M, et al. (1999) alpha-synuclein fibrillogenesis is nucleation-dependent. ❋ Diane Latawiec Et Al. (2010)
