To confirm that mTORC1 regulates JNK / c-Jun activation in response to ER stress, we studied the effect of thapsigargin, which is an ER stressor, and that of anisomycin, which activates JNK in an ER stress-independent manner. ❋ Etti Bachar Et Al. (2009)
Research on interaction of thapsigargin and certain cell membranes. ❋ Unknown (2004)
Co-treatment of the γ-secretase reporter cells with PBA blocked the repressive effects of tunicamycin and thapsigargin upon APP proteolysis, UPR activation, and apoptosis. ❋ Unknown (2010)
* Design and synthesis of SERCA inhibitors base don the pharmacophore of thapsigargin. ❋ Unknown (2010)
There were no significant differences in the time constants for the recovery of thapsigargin-evoked Ca ❋ Rodney P. O'Connor Et Al. (2010)
Effect of RF exposure on thapsigargin-induced Ca2+Signals. ❋ Rodney P. O'Connor Et Al. (2010)
Cells exposed to GSM RF fields at 1 of 7 SARs (0.012, 0.062, 0.125, 0.25, 0.5, 1 or 2 W/kg) for 30 minutes had similar peak thapsigargin-evoked Ca ❋ Rodney P. O'Connor Et Al. (2010)
Three unrelated pharmacological agents (tunicamycin, thapsigargin and brefeldin A) all repressed APP proteolysis in parallel with activation of unfolded protein response (UPR) signaling-a biochemical marker of ER stress. ❋ Unknown (2010)
Bii, RF exposure at a wide range of SARs showed no influence on the thapsigargin-induced peak Ca ❋ Rodney P. O'Connor Et Al. (2010)
B; Analysis of the Ca2+ signals evoked by addition of thapsigargin and extracellular Ca ❋ Rodney P. O'Connor Et Al. (2010)
A; illustration of the protocol used for thapsigargin experiments, showing the various ❋ Rodney P. O'Connor Et Al. (2010)
This is due to loss of the finite Ca2+ content within the ER and the progressive removal of the ion by plasma membrane ATPases that are insensitive to thapsigargin. ❋ Rodney P. O'Connor Et Al. (2010)
CHMFs subjected to tunicamycin or thapsigargin, compounds that inhibit protein glycosylation and disrupt ER calcium levels respectively inducing ER stress, also showed an increase in MstnPP expression (in addition to ER stress marker proteins GRP78 and Herp), possibly due to the activation of NF-κB ❋ Carlene S. Starck Et Al. (2010)
Addition of extracellular Ca2+ to thapsigargin-treated coverslides induced a large store-operated Ca ❋ Rodney P. O'Connor Et Al. (2010)
In the absence of extracellular Ca2+, thapsigargin causes a transient Ca ❋ Rodney P. O'Connor Et Al. (2010)
Cytosolic Ca2+ was manipulated in EA. hy926 cells through the application of thapsigargin during the exposure period. ❋ Rodney P. O'Connor Et Al. (2010)
