Titin

The authors wrote that synthetic biomaterials display the unique multifunctional characteristics of titin, acting like a spring with high resilience at low strain and as a shock-absorb at high strains. ❋ Unknown (2010)

Researchers engineered a polymer to reproduce the properties of titin - a protein which largely determines the elastic properties of muscle. ❋ Unknown (2010)

"A hallmark of titin-like proteins is that they unfold under a stretching force to dissipate energy and prevent damage to tissues by over-stretching," said co-author John ❋ Unknown (2010)

The team engineered a synthetic protein to reproduce the molecular structure of titin, the muscle protein "that largely governs the elastic properties of muscle," according to the Nature article. ❋ Unknown (2010)

The integrated optical density (OD) of N2BA titin, N2B titin, total titin (N2BA+N2B), and myosin heavy chain (MHC) were determined at each lane. ❋ Unknown (2009)

These first-ever measurements of mechanical stability in the titin-telethonin protein complex show it to be a highly "directed" bond, extremely strong but only along the lines of natural physiological stress. ❋ Unknown (2009)

I guess my research article on the mechanical unfolding of titin is not a high-hitter. ❋ Unknown (2009)

N2BA: the large more compliant isoform (3300 kDa) of titin, N2B: the smaller stiffer isoform (3000 kDa) of titin, nebulin ❋ Unknown (2009)

Hein S, Scholz D, Fujitani N, Rennollet H, Brand T, et al. (1994) Altered expression of titin and contractile proteins in failing human myocardium. ❋ Unknown (2009)

Shah G, Wu Y, Torre-Amione G, King NM, et al. (2004) Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy. ❋ Unknown (2009)

One key element is a bond involving titin, a giant among proteins. ❋ Unknown (2009)

Trombitas K, Witt CC, Labeit S, et al. (2002) Changes in titin isoform expression in pacing-induced cardiac failure give rise to increased passive muscle stiffness. ❋ Unknown (2009)

Simulations have pointed toward a network of tight hydrogen bonds linking titin and telethonin as a source of stability. ❋ Unknown (2009)

D, gel electrophoresis and densitometric analysis showing lowered titin protein levels and its isoforms in hypoxic E20 chick embryo hearts. ❋ Unknown (2009)

E, densitometric quantification of total titin composition (N2BA+N2B) showing decreased levels of total titin in the hearts of the hypoxic chick embryos, n = 7 in both groups. ❋ Unknown (2009)

The increase in the interstitial protein collagen and decrease in the sarcomeric proteins MHC and titin in hypoxic hearts might account for the observed changes ❋ Unknown (2009)

Data are shown as mean±SE; * P Expression of total titin, titin isoforms, titin isoforms / total titin ratios and titin / myosin ratios. doi: 10.1371 / journal. pone.0005155.t001 ❋ Unknown (2009)

Hypoxic chick embryos displayed severe LV dilatation just prior to hatching, which was accompanied by a reduced LV wall mass, increased apoptosis, as well as a lowered cardiac content of the sarcomeric proteins MHC and titin. ❋ Unknown (2009)

We also found reduced titin N2BA-to-N2B expression ratios in hypoxic chick hearts. ❋ Unknown (2009)