Owen published on the tolerogenic consequences of this placental intermingling of circulation (12). ❋ Unknown (1990)
Enrichment of T cells with regulatory activity may result in a tolerogenic environment during repopulation; and ❋ Unknown (2010)
"These abstracts demonstrate that, as a monotherapy, sCD83 is capable of inducing kidney allograft tolerance via the generation of tolerogenic dendritic cells, and that sCD83-mediated B cell suppression contributes to delayed graft rejection," said Dr. Hao Wang of the University of Western Ontario. ❋ Unknown (2009)
The presentations, to be made on March 7 by Argos 'collaborating scientists from the University of Western Ontario, detail positive preclinical data for sCD83 in organ transplantation models, as well its ability to induce and maintain immune tolerance via its generation of tolerogenic dendritic cells (DC) and its direct suppressive effects on T cells and B cells. ❋ Unknown (2009)
Svajger U, Vidmar A, Jeras M (2008) Niflumic acid renders dendritic cells tolerogenic and up-regulates inhibitory molecules ILT3 and ILT4. ❋ Devorah Gur-Wahnon Et Al. (2009)
Expression of ILT3 and ILT4 on DC has been associated with a tolerogenic phenotype which was shown to be crucial to the tolerogenic capacity acquired by DCs ❋ Devorah Gur-Wahnon Et Al. (2009)
Albeit their mature-like phenotype these latter cells express the tolerogenic markers ILT3 and ILT4 and possess T cell inhibitory activity. ❋ Devorah Gur-Wahnon Et Al. (2009)
The study described herein, identifies the first member of the TGF β/BMP family of stem cell regulators as a novel tolerogenic factor released by NPCs. ❋ Unknown (2009)
Michaelsson J, Burt TD, Muench MO, Beckerman KP, et al. (2008) Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. ❋ Karen May Et Al. (2009)
However, neither the identity nor the regulatory properties of these tolerogenic lymphocytes have been reported. ❋ Unknown (2009)
Interestingly, despite the marked differences in the overall phenotype between the contact - and soluble factor-dependent mechanisms the levels of expression of these two markers for tolerogenic APCs, ILT3 and ILT4 were upregulated in both DCs and monocytes co-cultured with hMSC or MCF-7 as well as when they were treated with IL-10 ( ❋ Devorah Gur-Wahnon Et Al. (2009)
Understanding the mechanisms by which preoperative DST induces the generation of tolerogenic Tregs in the presence of alloantigens may lead to the development of novel antigen-specific immunological therapies for the treatment of solid organ rejection. miR-155 Inhibition Sensitizes CD4+ Th Cells for TREG Mediated Suppression Ex Vivo Expanded Regulatory T Cells "> Suppression of Glomerulonephritis in NZB/NZW Lupus Prone Mice by Adoptive Transfer of ❋ Unknown (2009)
