Tophi

In tophaceous gout (which is marked by frequent recurrence), uric acid crystal deposits - called tophi - show up in the different tissues near the joints. ❋ Unknown (2007)

These nodular concretions are called tophi or chalkstones. ❋ A. W. Duncan (N/A)

Symptoms include severe pain in the joints that develop within a few hours, swelling and warmth around the joint, red and shiny skin, fever and firm, white lumps beneath the skin called tophi (if you have had gout for some time).

Cristales en los oídos puedan formar dolorosos nódulos llamados "tophi". ❋ Unknown (2008)

Bristol — a common prostitute, sir, who had got all the worst symptoms of the disorder; such as nodi, tophi, and gummata, verruca, cristoe Galli, and a serpiginous eruption, or rather a pocky itch all over her body. ❋ Unknown (2004)

The hyperuricemia of gout produces deposits of small crystals of uric acid in joints which results in extreme pain, or large deposits, tophi, which results in gouty arthritis and restricted joint movement. ❋ Unknown (1988)

Qui mæstos hyacinthos, et picti [Greek: anthea] tophi ❋ Henry Vaughan (1658)

The treatment appears safe and efficacious, reducing the number of gout tophi and the number of swollen joints and improving pain and health-related quality of life. ❋ Unknown (2010)

"There is good evidence that achieving serum urate levels to less than 6 mg/dl results in freedom from acute gout attacks, and shrinkage and eventual disappearance of tophi (deposits of monosodium urate crystals in people with longstanding high levels of uric acid in the blood)," he said. ❋ Unknown (2010)

It occurs when excess uric acid in the body is deposited as needle-like crystals, or tophi, in the joints or soft tissues, which cause inflammatory arthritis and can lead to gout flares typically lasting three to 10 days. ❋ Unknown (2010)

In these patients, the substantial reduction of sUA, coupled with increased excretion of uric acid associated with RDEA594's URAT1 mechanism, may lead to improved resolution of these tophi. ❋ Unknown (2010)

This leads to the deposition of painful, needle-like uric acid crystals in and around the connective tissue of the joints and in the kidneys, resulting in inflammation, the formation of disfiguring nodules (tophi), intermittent attacks of severe pain (acute flares) and kidney damage (nephropathy). ❋ Unknown (2010)

These levels of sUA reduction suggest the combination of RDEA594 and febuxostat may be particularly useful in patients who have accumulated large deposits of uric acid, or tophi. ❋ Unknown (2010)

Your doctor will examine you, and he or she will look at your painful joints and search your skin for tophi.

As we have stated previously, we believe that data contained in our BLA has amended demonstrates that KRYSTEXXA if approved as of the potential will be the first effective therapeutic option to not only control uric acid in treatment failure patients, but equally important to achieve unique medically relevant and meaningful clinical outcome including the complete elimination of tophi, reduction in flares, clinically meaningful improvements in physical function, and reductions in pain. ❋ Unknown (2009)

Other problems related to gout can include the formation of tophi, or lumps of crystals under the skin, in the joints and in bone; kidney stones; and impaired kidney function.

Topic: The Side Effects Of Crestor (Read 4 times) --- > > > The Side Effects Of Crestor relief but transversely when i have a overview up of my tophi like i do duac farther with my back. ❋ Unknown (2009)

But over time, the frequency increases and people can develop disfiguring and disabling lumps of the chalky white crystals, called tophi. ❋ Unknown (2009)

For people with more severe disease, long-term preventive medication is highly effective at lowering uric acid, which can prevent attacks and, over months to years, cause tophi to go away.