Transcytosis

Binding to LRP1 facilitates receptor-mediated transport, or transcytosis, across the BBB into the brain tissue. ❋ Unknown (2011)

This nano-shuttle system is believed to activate an albumin-specific (Gp60) receptor-mediated transcytosis path through the cell wall of proliferating tumor cells, using caveolin-1 activated caveolar transport. ❋ Unknown (2010)

The complex intracellular domain with many different motifs for internalization, phosphorylation and binding of cytosolic adaptor proteins seems on one hand to be involved in clearance of Aβ from the brain via endocytosis and subsequent intracellular breakdown and via transcytosis across the blood-brain-barrier to the blood, and on the other hand to be involved in regulation of Aβ production via modulation of ❋ Unknown (2010)

For instance, transcytosis of phenoloxidases from the haemolymph to the cuticle ❋ Michaela Norum Et Al. (2010)

B, Wisniewska J, et al. (2008) ARF GEF-dependent transcytosis and polar delivery of PIN auxin carriers in Arabidopsis. ❋ Ora Hazak Et Al. (2010)

ANG1005 is a novel taxane derivative created from the Engineered Peptide Compound (EPiC) platform that is designed to cross the blood-brain barrier (BBB) by receptor-mediated transcytosis, overcoming the BBB's normal function of blocking foreign substances which prevents more than 95 percent of all drugs from reaching the brain. www. aacr.org.

Alternately, a scenario in which CD penetrates the BBB but does not enter the neuron could involve entry into vascular endothelial cells where its effects are exerted from within these frontline BBB cells, or transcytosis across these cells followed by endocytosis into adjacent astrocytes. ❋ Cristin D. Davidson Et Al. (2009)