Trimethylation

"We observed that the addition of three methyl groups (a process known as trimethylation) on the fourth lysine of H3K4 is regulated by the active site of the yeast equivalent of the MLL protein complex, COMPASS," said Yoh-hei Takahashi, Ph. D., ❋ Unknown (2009)

Suz12, is essential for embryonic development; this gene encodes one of the components of the polycomb repressive complex 2 (PRC2), which catalyzes the di - and trimethylation of ❋ Atsushi Fukuda Et Al. (2010)

Lsh −/− cells, we examined H3K4 trimethylation (H3K4me3) and binding of Chd1. ❋ Yongguang Tao Et Al. (2010)

Histone 3 lysine 36 trimethylation (H3K36me3) and H3K79 dimethylation (H3K79me2) are present at fairly equal levels in cellular extracts of ❋ Yongguang Tao Et Al. (2010)

One particular histone modification, the trimethylation of amino acid lysine at position 27 of histone H3 -- or H3K27me3 -- is well-known to be associated with repression of some genes. ❋ Unknown (2009)

Coexistence of bivalent histone H3 lysine 27 trimethylation (H3K27me3) and H3K4me3 marks at the ❋ Unknown (2009)

H3K64 trimethylation marks heterochromatin and is dynamically remodeled during developmental reprogramming. ❋ Unknown (2009)

"We also demonstrated that a single residue (Tyr1052) functions with a known subunit of COMPASS (Cps40) to regulate the trimethylation of H3K4." ❋ Unknown (2009)