Ubiquitinated

When cells are exposed to bacteria or various signal substances, the inhibitor protein is phosphorylated, and this results in its being ubiquitinated and broken down in the proteasome. ❋ Unknown (2004)

The cell identifies these ubiquitinated molecules as "waste" and degrades them. ❋ PhysOrg Team (2010)

Moreover, the finding that dMfn is still weakly ubiquitinated in ❋ Angela C. Poole Et Al. (2010)

Caccamo AE, Belloni L, Bettuzzi S (2009) Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells. ❋ Hongyu Ying Et Al. (2010)

We report that dMfn is ubiquitinated in a PINK1 - and Parkin-dependent fashion, that the steady-state abundance of dMfn is inversely correlated to PINK1 and Parkin activity, and that Parkin co-immunoprecipitates with dMfn. ❋ Angela C. Poole Et Al. (2010)

Worn out proteins within the cell become ubiquitinated, marking them for proteasome degradation. ❋ Unknown (2010)

A prediction of this hypothesis is that a ubiquitinated form of dMfn exists, at least transiently, in wt flies, and that the abundance of this ubiquitinated form of dMfn will be substantially decreased in ❋ Angela C. Poole Et Al. (2010)

Figure 2E, higher levels of ubiquitinated HIF-1α were found in control cells either treated with the proteasome inhibitor MG132 under normoxia, either exposed to hypoxia, when compared to levels of ubiquitinated HIF-1α found in bcl-2 transfectants exposed to the same conditions. ❋ Daniela Trisciuoglio Et Al. (2010)

Zhao Y, Ashwell JD (2007) Optineurin negatively regulates TNFα - induced NF-κB activation by competing with NEMO for ubiquitinated RIP. ❋ Hongyu Ying Et Al. (2010)

FANCI-FANCD2 complex is ubiquitinated by an FA core complex containing eight FA proteins. ❋ Unknown (2010)

An independently generated anti-dMfn antiserum confirms that dMfn is ubiquitinated in a PINK1 - and Parkin-dependent fashion. ❋ Angela C. Poole Et Al. (2010)