In short, the authors found that the fat tissue from the obese co-twins showed a significant up-regulation of inflammatory pathways, significantly reduced mitochondrial DNA copy number, and disturbed mitochondrial energy metabolism — statistically most significantly, the decreased catabolism of branched-chain amino acids (BCAA). ❋ Unknown (2008)
Kavlock says the screens test for a range of end points, such as interactions with nuclear receptors, up-regulation of the p53 tumor suppressor gene, and effects on DNA repair mechanisms. ❋ Unknown (2009)
Sex-dependent up-regulation of two splicing factors, Psf and Srp20, during hippocampal memory formation. ❋ Unknown (2008)
For better or for worse: Neural systems supporting the cognitive down-and up-regulation of negative emotion. ❋ Andrew Newberg (2006)
The pro-apoptotic effects of miR-184 ectopic over-expression in neuroblastoma cell lines is reproduced by siRNA inhibition of AKT2, while a positive effect on cell proliferation similar to that obtained by the knock-down of endogenous miR-184 can be achieved by ectopic up-regulation of AKT2. ❋ Niamh Foley (2010)
In fibroblasts of reconstructed skin, DUVR led to significant up-regulation of four out of the five tested Nrf2 target genes. ❋ Claire Marionnet Et Al. (2010)
While cluster 1 parasites, representing a starvation response, show up-regulation of organellar chaperones, cluster 2 parasites, which resemble active growth based on glycolysis, show up-regulation of cytoplasmic chaperones. ❋ Rani Pallavi (2010)
This up-regulation of VEGF-A mRNA was accompanied by an increased secretion of VEGF-A proteins fully active in stimulating vascular endothelial cells (EC). ❋ S Dedieu (2010)
A recent study has demonstrated that clinical isolates of the parasite have distinct physiological states, one of which resembles environmental stress response showing up-regulation of specific molecular chaperones. ❋ Rani Pallavi (2010)
* Resveratrol mimics life extension effects of caloric restriction through sirtuin up-regulation and modulation of signaling pathways. ❋ Amp;34;Nutrition (2010)
Understanding this unique molecular mechanism could lead to identifying MPCs as feasible, long telomeres, target cells for reprogramming with no up-regulation of the p53 pathway. ❋ PLoS ONE (2010)
Furthermore, up-regulation of SHP by the high-KAA diet in both strains of mice under HFD feeding can be reasonably understood because ❋ Yasushi Noguchi Et Al. (2010)
We demonstrate that the knock-down of endogenous miR-184 has the opposite effect of ectopic up-regulation, leading to enhanced neuroblastoma cell proliferation. ❋ Niamh Foley (2010)
"Although these data are provocative, there are several outstanding questions that need to be addressed; namely, what are the mechanisms of capsaicin up-regulation of TRPV1 protein levels" ❋ Unknown (2010)
In addition, down-regulation of SHP as well as up-regulation of ❋ Yasushi Noguchi Et Al. (2010)
The study's findings suggest that TRPV1 activation is required to enhance eNOS activity, however the researchers also state that there is no way to exclude the possibility that other mechanisms may also contribute to the up-regulation of eNOS activity during prolonged capsaicin consumption. ❋ Unknown (2010)
Y, Ando A, Shiba E, Taguchi T, Tamaki Y, et al. (2001) Involvement of up-regulation of ❋ Matthias Negri Et Al. (2010)
Effects of trehalose injection on expressions of key genes in the chitin biosynthesis pathway In addition to the down-regulation of trehalase expression, an examination of an indirect up-regulation of trehalases by the injection of trehalose was conducted. ❋ Jie Chen Et Al. (2010)
