"We look for 2006 to be an important year for Sangamo with significant data demonstrating initial safety, efficacy and proof-of-concept of zinc-finger therapeutics," wrote analyst Edward Tenthoff, in a client note. ❋ Unknown (2006)
Interestingly, dual-coding transcripts were significantly enriched for transcripts from the zinc-finger protein family, which are usually DNA-binding proteins involved in regulation of the transcription process. ❋ Heng Xu (2010)
Cost GJ, Freyvert Y, Zeitler B, Miller JC, et al. (2009) Knockout rats via embryo microinjection of zinc-finger nucleases. ❋ Tomoji Mashimo Et Al. (2010)
Chen W, Liang Y, Deng W, Shimizu K, Ashique AM, et al. (2003) The zinc-finger protein CNBP is required for forebrain formation in the mouse. ❋ Morgan A. Sammons Et Al. (2010)
Genomic DNA (T: tail, B: brain, H: heart, L: liver) was used as a template for PCR in zinc-finger nuclease-modified founders (numbers 28, 35, 40, and 53) and G1 rats. ❋ Tomoji Mashimo Et Al. (2010)
Engineered zinc-finger transcription factors (ZF-TF) are powerful tools to modulate the expression of specific genes. ❋ Beatriz Gonzalez (2010)
Miller JC, Lee YL, Beausejour CM, Rock JM, et al. (2005) Highly efficient endogenous human gene correction using designed zinc-finger nucleases. ❋ Tomoji Mashimo Et Al. (2010)
The zinc-finger transcription factor GLI3 is an important mediator of Sonic hedgehog signaling and crucial for patterning of many aspects of the vertebrate body plan. ❋ Amir Abbasi (2010)
Figure 6: Roquin binds to ICOS mRNA through its ROQ and zinc-finger domains. ❋ Elke Glasmacher (2010)
Here we report on a novel human RING finger protein, ZNF645, which contains a C3HC4 RING finger domain, a C2H2 zinc-finger domain, and a proline-rich region, indicating that it has a structure similar to that of the c-Cbl-like protein Hakai. ❋ Yun-Qiang Liu (2010)
Several DNA repair and checkpoint proteins possess specific PAR-binding zinc-finger (PBZ) modules critical for function. ❋ Sebastian Eustermann (2010)
PCR analysis of 13 mutant founders for the zinc-finger nuclease (ZFN) target site. ❋ Tomoji Mashimo Et Al. (2010)
Tristetraprolin (TTP or ZFP36) is a tandem CCCH zinc-finger RNA-binding protein that regulates the stability of certain AU-rich element (ARE) mRNAs. ❋ N Al-Souhibani (2010)
Intercrossing of zinc-finger nuclease-modified founders between males and females. ❋ Tomoji Mashimo Et Al. (2010)
Hockemeyer D, Soldner F, Beard C, Gao Q, Mitalipova M, et al. (2009) Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. ❋ Tomoji Mashimo Et Al. (2010)
TTP targets were probed using a novel approach by expressing the C124R zinc-finger TTP mutant that functions as dominant negative and increases target mRNA expression. ❋ N Al-Souhibani (2010)
Recently, zinc-finger nucleases (ZFNs) were successfully used to create genome-specific double-stranded breaks and thereby induce targeted gene mutations in a wide variety of organisms including plants, drosophila, zebrafish, etc. ❋ Tomoji Mashimo Et Al. (2010)
